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Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice

Zarei, Mahsa ; Shivanandappa, T.

Food and chemical toxicology, 2013-07, Vol.57, p.179-184 [Peer Reviewed Journal]

Oxford: Elsevier Ltd

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Title:
Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice
Author: Zarei, Mahsa ; Shivanandappa, T.
Subjects: alanine ; alanine transaminase ; Alanine Transaminase - blood ; Alanine Transaminase - genetics ; Alanine Transaminase - metabolism ; alkaline phosphatase ; Alkaline Phosphatase - blood ; Alkaline Phosphatase - genetics ; Alkaline Phosphatase - metabolism ; Animals ; antioxidant activity ; Antioxidant enzymes ; antioxidants ; Antioxidants - metabolism ; Apocynaceae - chemistry ; Aspartate Aminotransferases - blood ; Aspartate Aminotransferases - genetics ; Aspartate Aminotransferases - metabolism ; aspartate transaminase ; Biological and medical sciences ; blood serum ; Carcinogenesis, carcinogens and anticarcinogens ; catalase ; Catalase - metabolism ; Chemical agents ; Cyclophosphamide ; Cyclophosphamide - toxicity ; Decalepis hamiltonii ; drug therapy ; Enzymes - blood ; Enzymes - genetics ; Enzymes - metabolism ; gene expression regulation ; Gene Expression Regulation, Enzymologic - drug effects ; genes ; glutathione ; glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; glutathione transferase ; Glutathione Transferase - metabolism ; glutathione-disulfide reductase ; Hepatotoxicity ; lactate dehydrogenase ; lipid peroxidation ; Lipid Peroxidation - drug effects ; liver ; Liver - drug effects ; Liver - pathology ; Medical sciences ; Mice ; oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Protective Agents - pharmacology ; reactive oxygen species ; roots ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Toxicology ; Tumors
Is Part Of: Food and chemical toxicology, 2013-07, Vol.57, p.179-184
Notes: http://dx.doi.org/10.1016/j.fct.2013.03.028
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Description: •The hepatoprotective potential of DHA against CP-induced liver damage.•DHA prevented the elevation of serum marker enzymes in CP-treated mice.•DHA enhanced the antioxidant defenses in the liver in vivo.•DHA inhibited down-regulation of antioxidant enzymes gene expressions. Hepatoprotective potential of the aqueous extract of the roots of Decalepis hamiltonii (DHA) against cyclophosphamide (CP)-induced oxidative stress has been investigated in mice. Administration of CP (25mg/kg b.w., i.p) for 10days induced hepatic damage as indicated by the serum marker enzymes aspartate and alanine transaminases (AST, ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Parallel to these changes CP induced oxidative stress in the liver as evident from the increased lipid peroxidation (LPO), reactive oxygen species (ROS), depletion of glutathione (GSH), and reduced activities of the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST). Treatment with DHA (50 and 100mg/kg b.w., po) mitigated the CP-induced oxidative stress. Moreover, expression of genes for the antioxidant enzymes, were down-regulated by CP treatment which was reversed by DHA. Our study shows the DHA protected the liver from toxicity induced by CP and therefore, it could be serve as a safe medicinal supplement during cyclophosphamide chemotherapy.
Publisher: Oxford: Elsevier Ltd
Language: English

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Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice

Zarei, Mahsa ; Shivanandappa, T.

Oxford: Elsevier Ltd

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