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Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71

Yu, Liqin ; Liu, Chunsheng ; Chen, Qi ; Zhou, Bingsheng

Environmental toxicology and chemistry, 2014-06, Vol.33 (6), p.1354-1362 [Periódico revisado por pares]

Pensacola, FL: Blackwell Publishing Ltd

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Título:
Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71
Autor: Yu, Liqin ; Liu, Chunsheng ; Chen, Qi ; Zhou, Bingsheng
Assuntos: Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Danio rerio ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Embryology: invertebrates and vertebrates. Teratology ; Embryos ; Endocrine disruption ; Endocrine Disruptors - toxicity ; Environmental Exposure - adverse effects ; Female ; Females ; Fish ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes ; Gonadal Steroid Hormones - blood ; Halogenated Diphenyl Ethers - toxicity ; Hormones ; Male ; Males ; Ovary - drug effects ; Ovary - growth & development ; Ovum - drug effects ; Ovum - physiology ; Polybrominated diphenyl ethers (PBDEs) ; Reproduction - drug effects ; Reproductive toxicity ; Ribonucleic acid ; RNA ; Sex hormone ; Steroids ; Teratology. Teratogens ; Testis - drug effects ; Testis - growth & development ; Time Factors ; Toxicity ; Transcriptome - drug effects ; Water Pollutants, Chemical - toxicity ; Zebrafish ; Zebrafish - blood ; Zebrafish - genetics ; Zebrafish - growth & development ; Zebrafish - physiology
É parte de: Environmental toxicology and chemistry, 2014-06, Vol.33 (6), p.1354-1362
Notas: National Environmental Protection Public Welfare Science and Technology Research Program of China - No. 201309047
ArticleID:ETC2562
istex:A8CE1E3AA5937D9D6C357A99D46A97D4FE3460A9
National Natural Science Foundation of China - No. 21237005
ark:/67375/WNG-QX2N136M-5
State Key Laboratory of Freshwater Ecology and Biotechnology - No. 2011FBZ13
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The objective of the present study was to investigate the impact of polybrominated diphenyl ethers (PBDEs) on fish reproduction over 2 generations. Zebrafish (Danio rerio) embryos (F0) were exposed to low concentrations (3 µg/L, 10 µg/L, and 30 µg/L) of the PBDE mixture DE‐71 until they were sexually mature, and steroid hormone production, expression of genes involved in steroidogenesis, gonadal development, and gamete characteristics were examined. Exposure of female zebrafish to DE‐71 resulted in lower estradiol production and downregulation of cytochrome P450 aromatase mRNA. In males, exposure to DE‐71 resulted in greater testosterone production and greater cytochrome P450 c17 α‐hydroxylase,17,20‐lase mRNA expression. Moreover, hepatic vitellogenin mRNA and estrogenic receptor β gene transcription were downregulated in females and males. Expression of the follicle‐stimulating hormone β gene in the pituitary was upregulated, and the expression of luteinizing hormone β was downregulated in both sexes. Histological examination showed inhibition of oocyte maturation in females and retarded spermiation in males. The average number of eggs (F1) produced was also reduced. Additionally, exposure of F0 embryos to DE‐71 did not result in developmental toxicity, whereas delayed hatching, reduced survival, and decreased growth were observed in the F1 embryos derived from parent fish exposed to DE‐71. Therefore, long‐term exposure to low concentrations of PBDEs in zebrafish could cause reproductive impairment, suggesting that PBDEs might have significant adverse effects on fish population in the highly PBDEs‐contaminated aquatic environment. Environ Toxicol Chem 2014;33:1354–1362. © 2014 SETAC
Editor: Pensacola, FL: Blackwell Publishing Ltd
Idioma: Inglês

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Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71

Yu, Liqin ; Liu, Chunsheng ; Chen, Qi ; Zhou, Bingsheng

Pensacola, FL: Blackwell Publishing Ltd

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