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ADT risks and side effects in advanced prostate cancer: cardiovascular and acute renal injury
Crawford, E David ; Moul, Judd W
Oncology (Williston Park, N.Y.), 2015-01, Vol.29 (1), p.55-58
[Periódico revisado por pares]
United States: MJH Life Sciences Media
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Título:
ADT risks and side effects in advanced prostate cancer: cardiovascular and acute renal injury
Autor:
Crawford, E David
;
Moul, Judd W
Assuntos:
Acute Kidney Injury - chemically induced
;
Acute Kidney Injury - diagnosis
;
Androgen Antagonists - adverse effects
;
Cardiovascular diseases
;
Cardiovascular Diseases - chemically induced
;
Cardiovascular Diseases - diagnosis
;
Care and treatment
;
Complications and side effects
;
Hormone therapy
;
Humans
;
Kidney diseases
;
Male
;
Prostate cancer
;
Prostatic Neoplasms - drug therapy
;
Risk Factors
É parte de:
Oncology (Williston Park, N.Y.), 2015-01, Vol.29 (1), p.55-58
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
Androgen deprivation therapy (ADT) is key to the treatment of men with advanced prostate cancer. ADT can consist of surgical (bilateral orchiectomy) or medical strategies (eg, luteinizing hormone-releasing hormone agonists or gonadotropin-releasing hormone [GnRH] antagonists). The substantial reduction of testosterone levels achieved with ADT is associated with numerous well-characterized side effects, the management of which are key to patients' quality of life. More recently, a group of metabolic changes (dyslipidemia, hyperglycemia, others) that carry an increased risk of diabetes and cardiovascular disease have been reported in men receiving ADT. We review recent evidence suggesting an increased risk of pneumonia, cardiovascular disease, and acute kidney injury in men treated with ADT and consider whether the incidence of such events differs with the treatment modality. We discuss possible mechanisms by which such events might be mediated, including the roles of testosterone and the GnRH receptor, and consider current guidelines in light of these data.
Editor:
United States: MJH Life Sciences Media
Idioma:
Inglês
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