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Influence of Low-Level Exposure to Fusarium Mycotoxins on Selected Immunological and Hematological Parameters in Young Swine

Rotter, B.A. ; Thompson, B.K. ; Lessard, M. ; Trenholm, H.L. ; Tryphonas, H.

Fundamental and applied toxicology, 1994-07, Vol.23 (1), p.117-124

Boston, MA: Elsevier Science (USA)

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Título:
Influence of Low-Level Exposure to Fusarium Mycotoxins on Selected Immunological and Hematological Parameters in Young Swine
Autor: Rotter, B.A. ; Thompson, B.K. ; Lessard, M. ; Trenholm, H.L. ; Tryphonas, H.
Assuntos: ALBUMINAS ; ALBUMINE ; Animal Feed - toxicity ; Animals ; ANTICORPS ; ANTICUERPOS ; Biological and medical sciences ; Body Weight - drug effects ; CERDO ; DIETA ; EFECTOS SECUNDARIOS ; EFFET SECONDAIRE ; ERITROCITOS ; ERYTHROCYTE ; ESTOMAC ; ESTOMAGO ; FUSARIUM ; Fusarium - pathogenicity ; GLANDULA TIROIDE ; GLOBULINAS ; GLOBULINE ; Hematopoiesis - drug effects ; Immune System - drug effects ; IMMUNISATION ; INGESTION DE PIENSOS ; INMUNIZACION ; MAIS ; MAIZ ; Medical sciences ; MICOTOXINAS ; MYCOTOXINE ; Mycotoxins - toxicity ; Organ Size - drug effects ; OVIN ; OVINOS ; Plant poisons toxicology ; PORCIN ; PRISE ALIMENTAIRE (ANIMAUX) ; REGIME ALIMENTAIRE ; Swine - blood ; Swine - immunology ; TEMPERATURA DEL CUERPO ; TEMPERATURE CORPORELLE ; THYROIDE ; TOXICIDAD POR INGESTION ; TOXICITE PAR INGESTION ; TOXICOLOGIA ; TOXICOLOGIE ; Toxicology ; Trichothecenes - toxicity ; Zearalenone - toxicity
É parte de: Fundamental and applied toxicology, 1994-07, Vol.23 (1), p.117-124
Notas: L74
Q53
9531602
ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Influence of Low-Level Exposure to Fusarium Mycotoxins on Selected Immunological and Hematological Parameters in Young Swine. Rotter, B. A., Thompson, B. K., Lessard, M., Trenholm, N. L., and Trypbonas, H. (1994). Fundam. Appl. Toxicol. 23, 117-124. The effects of low dietary concentrations of Fusarium mycotoxins (deoxynivalenol (DON), 15-acetyl-DON, and zearalenone) on growth, immunological, and hematological parameters were determined in young pigs during a 28-day feeding experiment. Clean and naturally contaminated corn were incorporated into basal diets formulated to contain 0.00, 0.75, 1.50, and 3.00 mg DON/kg diet. A pair-fed control animal was used for comparison with each animal receiving the highest level of contamination (diet 4). Skin temperature, measured during the first week of the experiment, decreased linearly as the dietary mycotoxin concentration increased. Several other linear effects were observed: depressed feed intake throughout the experiment, reduction in thyroid size (absolute/relative), and changes in the appearance of the esophageal region of the stomach (thicker and higher degree of folding with increasing toxin concentration). Serum T4 (thyroxine) levels increased quadratically after 7 and 28 days of exposure compared to control animals. This change coincided with an increase in albumin levels, a decrease in α-globulin levels, and an overall increase in albumin/globulin ratio as the level of contamination increased. After immunization with sheep red blood cells (SRBC), animals fed contaminated diets showed a delayed response in peak titers. At the end of the experiment an increase in the segmented neutrophil count was observed. The following observations were made for animals consuming diet 4 as compared to the pair-fed controls: lower skin temperature, better feed efficiency, more corrugated stomachs, reduced α-globulin levels, and lower antibody titers to SRBC. The study showed a physiobiochemical adaptation response of animals exposed to mycotoxin-contaminated diets. Although most changes seem to be related to the nutritional status of the animal, others such as reduced skin temperature, altered stomach condition, and reduced α-globulin levels suggest specific effects due to the Fusarium toxins. The pair-feeding treatment was important in reaching these conclusions, but it is also evident that the treatment itself introduces changes in response to a reduced feed intake.
Editor: Boston, MA: Elsevier Science (USA)
Idioma: Inglês

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Influence of Low-Level Exposure to Fusarium Mycotoxins on Selected Immunological and Hematological Parameters in Young Swine

Rotter, B.A. ; Thompson, B.K. ; Lessard, M. ; Trenholm, H.L. ; Tryphonas, H.

Boston, MA: Elsevier Science (USA)

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