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Risk of subsequent in situ and invasive breast cancer in human epidermal growth factor receptor 2-positive ductal carcinoma in situ

Curigliano, G ; Disalvatore, D ; Esposito, A ; Pruneri, G ; Lazzeroni, M ; Guerrieri-Gonzaga, A ; Luini, A ; Orecchia, R ; Goldhirsch, A ; Rotmensz, N ; Bonanni, B ; Viale, G

Annals of oncology, 2015-04, Vol.26 (4), p.682-687 [Periódico revisado por pares]

England

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Título:
Risk of subsequent in situ and invasive breast cancer in human epidermal growth factor receptor 2-positive ductal carcinoma in situ
Autor: Curigliano, G ; Disalvatore, D ; Esposito, A ; Pruneri, G ; Lazzeroni, M ; Guerrieri-Gonzaga, A ; Luini, A ; Orecchia, R ; Goldhirsch, A ; Rotmensz, N ; Bonanni, B ; Viale, G
Assuntos: Adult ; Aged ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - therapy ; Carcinoma, Intraductal, Noninfiltrating - metabolism ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Carcinoma, Intraductal, Noninfiltrating - therapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Incidence ; Italy - epidemiology ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Retrospective Studies ; Risk Factors
É parte de: Annals of oncology, 2015-04, Vol.26 (4), p.682-687
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: To assess the prognostic role of human epidermal growth factor receptor 2 (HER2) overexpression in patients with ductal carcinoma in situ (DCIS). We identified patients with HER2-positive DCIS among a population of 1667 cases, prospectively diagnosed and surgically treated at the European Institute of Oncology from 1996 to 2008. Rates of subsequent DCIS or invasive cancer in HER2-positive disease were estimated. We evaluated Cumulative Incidence of In Situ Breast Cancer Recurrence (isBCR), INvasive Breast Cancer Recurrence (IBCR) and any Breast Cancer Recurrence (BCR). isBCR, IBCR and BCR were defined as the time from surgery to breast cancer recurrence as first event (in situ, invasive or both, respectively) or last visit in case of no events. We identified 560 (33.5%) patients with HER2-positive DCIS. The median follow-up was 7.6 years (interquartile range 5.9-9.5). We observed 422 events out of 1667 patients, with 141 in situ recurrences, 201 invasive recurrences and 80 other events (64 second primaries and 16 deaths). The 10-year isBCR proportions were 11.8% [95% confidence interval (CI) 9.0% to 15.4%] in the HER2-positive group and 8.8% (95% CI 6.9% to 11.0%) in the HER2-negative group (Gray test, P = 0.010). At multivariable analysis, the adjusted risk of isBCR was higher in the HER2-positive group than in the HER2-negative group [hazard ratio (HR) HER2 positive versus negative: 1.59 (95% CI 1.06-2.39)]. We observed significant differences both in BCR and isBCR for patients treated by quadrantectomy without radiotherapy versus patients treated with radiotherapy [adjusted HR HER2 positive versus negative: 1.53 (95% CI 1.07-2.18) and adjusted HR HER2 positive versus negative: 2.18 (95% CI 2.18-3.69), respectively]. HER2 overexpression predicts an increased risk of isBCR. Radiotherapy reduces local failure rates in HER2-positive DCIS.
Editor: England
Idioma: Inglês

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Risk of subsequent in situ and invasive breast cancer in human epidermal growth factor receptor 2-positive ductal carcinoma in situ

Curigliano, G ; Disalvatore, D ; Esposito, A ; Pruneri, G ; Lazzeroni, M ; Guerrieri-Gonzaga, A ; Luini, A ; Orecchia, R ; Goldhirsch, A ; Rotmensz, N ; Bonanni, B ; Viale, G

England

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