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A concise synthesis of tetrahydroisoquinoline-1-carboxylic acids using a Petasis reaction and Pomeranz–Fritsch–Bobbitt cyclization sequence

Chrzanowska, Maria ; Grajewska, Agnieszka ; Meissner, Zofia ; Rozwadowska, Maria ; Wiatrowska, Iwona

Tetrahedron, 2012-04, Vol.68 (14), p.3092-3097 [Peer Reviewed Journal]

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Title:
A concise synthesis of tetrahydroisoquinoline-1-carboxylic acids using a Petasis reaction and Pomeranz–Fritsch–Bobbitt cyclization sequence
Author: Chrzanowska, Maria ; Grajewska, Agnieszka ; Meissner, Zofia ; Rozwadowska, Maria ; Wiatrowska, Iwona
Subjects: Amines ; Chemistry ; Exact sciences and technology ; Heterocyclic compounds ; Heterocyclic compounds with only one n hetero atom and condensed derivatives ; Hydrochlorides ; Organic chemistry ; Petasis reaction ; Pomeranz–Fritsch–Bobbitt cyclization ; Preparations and properties ; Synthesis (chemistry) ; Tetrahedrons ; Tetrahydroisoquinoline-1-carboxylic acids
Is Part Of: Tetrahedron, 2012-04, Vol.68 (14), p.3092-3097
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: A sequence of two reactions: the Petasis reaction, in which an aminoacetaldehyde acetal was used as the amine component, followed by Pomeranz–Fritsch–Bobbitt cyclization, has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline-1-carboxylic acids. Using this method several acids have been prepared in good to excellent yields and characterized as hydrochloride salts. [Display omitted]
Publisher: Kidlington: Elsevier Ltd
Language: English

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