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New advances in the diagnosis and treatment of POEMS syndrome

Li, Jian ; Zhou, Dao‐bin

British journal of haematology, 2013-05, Vol.161 (3), p.303-315 [Revista revisada por pares]

Oxford: Blackwell

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Título:
New advances in the diagnosis and treatment of POEMS syndrome
Autor: Li, Jian ; Zhou, Dao‐bin
Materias: Antibodies, Monoclonal, Humanized - therapeutic use ; autologous peripheral blood stem cell transplantation ; Bevacizumab ; Biological and medical sciences ; Boronic Acids - therapeutic use ; Bortezomib ; Castleman Disease - etiology ; Chromosome Aberrations ; Combined Modality Therapy ; Dexamethasone - administration & dosage ; Dexamethasone - therapeutic use ; Disease Management ; Drug Therapy, Combination ; Genes, Immunoglobulin ; Hematologic and hematopoietic diseases ; Humans ; Hypertension, Pulmonary - etiology ; lenalidomide ; Medical sciences ; melphalan ; Melphalan - administration & dosage ; Melphalan - therapeutic use ; Osteosclerosis - etiology ; Peripheral Blood Stem Cell Transplantation ; Plasma Cells - pathology ; POEMS syndrome ; POEMS Syndrome - diagnosis ; POEMS Syndrome - etiology ; POEMS Syndrome - therapy ; Prognosis ; Pyrazines - therapeutic use ; Severity of Illness Index ; Symptom Assessment ; Thalidomide - administration & dosage ; Thalidomide - analogs & derivatives ; Thalidomide - therapeutic use ; Transplantation, Autologous ; Tumors ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - antagonists & inhibitors ; Vascular Endothelial Growth Factor A - blood ; Vascular Endothelial Growth Factor A - physiology
Es parte de: British journal of haematology, 2013-05, Vol.161 (3), p.303-315
Notas: ObjectType-Article-2
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Descripción: Summary POEMS syndrome is a clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Significant advances have been made in the diagnosis and treatment of POEMS syndrome over the last decade. Herein, the diagnostic criteria and characteristic features are reviewed, focusing the role of characteristic features in early diagnoses. Autologous peripheral blood stem cell transplantation has become the first‐line treatment for younger patients with normal organ function. Autologous transplantation has resulted in a high response rate and durable remission. Moreover, transplantation‐related morbidity and mortality has been significantly reduced over the past 5 years. Induction therapy before transplantation may improve the harvest of stem cells and decrease transplantation‐related morbidity. Melphalan and dexamethasone is an effective and well‐tolerated treatment for older patients or those with organ dysfunction. Novel agents may also offer benefits to patients with a poor performance status or renal dysfunction, and transform transplantation eligibility.
Editor: Oxford: Blackwell
Idioma: Inglés

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New advances in the diagnosis and treatment of POEMS syndrome

Li, Jian ; Zhou, Dao‐bin

Oxford: Blackwell

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