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Tempol prevents chronic sleep-deprivation induced memory impairment

Alzoubi, Karem H ; Khabour, Omar F ; Albawaana, Amal S ; Alhashimi, Farah H ; Athamneh, Rabaa Y

Brain research bulletin, 2016-01, Vol.120, p.144-150 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Tempol prevents chronic sleep-deprivation induced memory impairment
Autor: Alzoubi, Karem H ; Khabour, Omar F ; Albawaana, Amal S ; Alhashimi, Farah H ; Athamneh, Rabaa Y
Assuntos: Administration, Oral ; Animals ; Antioxidants - pharmacology ; Cyclic N-Oxides - pharmacology ; Disease Models, Animal ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Male ; Maze ; Maze Learning - drug effects ; Maze Learning - physiology ; Memory ; Memory Disorders - etiology ; Memory Disorders - metabolism ; Memory Disorders - prevention & control ; Memory, Long-Term - drug effects ; Memory, Long-Term - physiology ; Memory, Short-Term - drug effects ; Memory, Short-Term - physiology ; Motor Activity - drug effects ; Motor Activity - physiology ; Neurology ; Nootropic Agents - pharmacology ; Random Allocation ; Rats, Wistar ; Sleep deprivation ; Sleep Deprivation - complications ; Sleep Deprivation - drug therapy ; Sleep Deprivation - metabolism ; Sleep Deprivation - psychology ; Spatial Memory - drug effects ; Spatial Memory - physiology ; Spin Labels ; Tempol
É parte de: Brain research bulletin, 2016-01, Vol.120, p.144-150
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Highlights • We confirmed that chronic sleep deprivation impairs short- and long-term memories. • It also reduced hippocampal antioxidant mechanisms. • Tempol, on the other hand, prevented sleep deprivation-induced memory impairments. • It also normalized hippocampus antioxidant mechanisms during sleep deprivation. • Thus, tempol could be acting through its antioxidant effect on the hippocampus.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Tempol prevents chronic sleep-deprivation induced memory impairment

Alzoubi, Karem H ; Khabour, Omar F ; Albawaana, Amal S ; Alhashimi, Farah H ; Athamneh, Rabaa Y

United States: Elsevier Inc

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