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Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study

Oki, Erica, M.Sc ; Norde, Marina M., M.Sc ; Carioca, Antônio A.F., M.Sc ; Ikeda, Renata E., B.Sc ; Souza, José M.P., Ph.D ; Castro, Inar A., Ph.D ; Marchioni, Dirce M.L., Ph.D ; Fisberg, Regina M., Ph.D ; Rogero, Marcelo M., Ph.D

Nutrition (Burbank, Los Angeles County, Calif.), 2016-01, Vol.32 (1), p.88-94 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study
Autor: Oki, Erica, M.Sc ; Norde, Marina M., M.Sc ; Carioca, Antônio A.F., M.Sc ; Ikeda, Renata E., B.Sc ; Souza, José M.P., Ph.D ; Castro, Inar A., Ph.D ; Marchioni, Dirce M.L., Ph.D ; Fisberg, Regina M., Ph.D ; Rogero, Marcelo M., Ph.D
Assuntos: Adult ; Alleles ; Biomarkers - blood ; Blood Pressure ; Brazil ; C-Reactive Protein - genetics ; Cholesterol ; Cross-Sectional Studies ; CRP gene polymorphism ; Cytokines - blood ; Fatty acids ; Fatty Acids - blood ; Gastroenterology and Hepatology ; Gene-diet interaction ; Genotype ; Humans ; Inflammation - blood ; Inflammation - genetics ; Inflammation Mediators - blood ; Inflammatory biomarkers ; Middle Aged ; Nutrigenetics ; Plasma ; Plasma fatty acid ; Polymorphism, Single Nucleotide ; Rodents ; Triglycerides - blood ; Waist Circumference ; Young Adult
É parte de: Nutrition (Burbank, Los Angeles County, Calif.), 2016-01, Vol.32 (1), p.88-94
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SourceType-Scholarly Journals-1
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Descrição: Abstract Objective To assess the interaction of three single nucleotide polymorphisms in the C-reactive protein (CRP) gene and plasma fatty acid (FA) levels in modulating inflammatory profile. Methods A total of 262 subjects, aged >19 y and <60 y, participated in a cross-sectional, population-based study performed in Brazil. Three single nucleotide polymorphisms (rs1205, rs1417938, and rs2808630) spanning the CRP gene were genotyped. Eleven plasma inflammatory biomarkers and plasma FA profile were determined. Cluster analysis was performed to stratify individuals based on eleven inflammatory biomarkers into two groups: an inflammatory (INF) and a noninflammatory group. Results The INF cluster had higher age, waist circumference, systolic blood pressure, and diastolic blood pressure; higher levels of triacylglycerol, high-sensitivity CRP, tumor necrosis factor-α, interleukin (IL)-8, IL-6, IL-1β, IL-12, IL-10, soluble monocyte chemoattractant protein-1, soluble intercellular adhesion molecule-1, C16:0, polyunsaturated fatty acid, and omega (n)-6 polyunsaturated fatty acid; and greater C20:4n-6, C18:1/18:0, and C20:4/20:3 ratios than the noninflammatory group. Statistically significant gene-plasma C16:1n-7 interaction was detected for rs1417938 ( P = 0.047). Those with a dominant homozygous rs2808630 had a lower risk of belonging to the INF group with the upper 50th percentile of C20:4n-6, n-3 highly unsaturated FA, and C20:4/20:3 ratio. Regarding rs1205, A allele carriers had lower risk of being in the INF group when C20:5n-3 and n-3 highly unsaturated FA levels were greater than the median. Conclusions The INF group exhibited changes in metabolic parameters that predispose this group to chronic disease, where polymorphisms in the CRP gene modulated the risk of being in the INF group depending on individual plasma fatty acid and lipid profile.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study

Oki, Erica, M.Sc ; Norde, Marina M., M.Sc ; Carioca, Antônio A.F., M.Sc ; Ikeda, Renata E., B.Sc ; Souza, José M.P., Ph.D ; Castro, Inar A., Ph.D ; Marchioni, Dirce M.L., Ph.D ; Fisberg, Regina M., Ph.D ; Rogero, Marcelo M., Ph.D

United States: Elsevier Inc

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