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Toxicological effects of benzo(a)pyrene, DDT and their mixture on the green mussel Perna viridis revealed by proteomic and metabolomic approaches

Song, Qinqin ; Chen, Hao ; Li, Yuhu ; Zhou, Hailong ; Han, Qian ; Diao, Xiaoping

Chemosphere (Oxford), 2016-02, Vol.144, p.214-224 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Toxicological effects of benzo(a)pyrene, DDT and their mixture on the green mussel Perna viridis revealed by proteomic and metabolomic approaches
  • Autor: Song, Qinqin ; Chen, Hao ; Li, Yuhu ; Zhou, Hailong ; Han, Qian ; Diao, Xiaoping
  • Assuntos: Animals ; Benzo(a)pyrene ; Benzo(a)pyrene - chemistry ; Benzo(a)pyrene - toxicity ; Binary mixture ; DDT ; DDT - chemistry ; DDT - toxicity ; Environmental Monitoring - methods ; Gills - drug effects ; Gills - metabolism ; Male ; Metabolomics ; Metabolomics - methods ; Oxidative Stress - drug effects ; Perna - drug effects ; Perna - metabolism ; Perna viridis ; Proteomics ; Proteomics - methods ; Water Pollutants, Chemical - chemistry ; Water Pollutants, Chemical - toxicity
  • É parte de: Chemosphere (Oxford), 2016-02, Vol.144, p.214-224
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Benzo(a)pyrene (BaP) and dichlorodiphenyltrichloroethane (DDT) are persistent organic pollutants and environmental estrogens (EEs) with known toxicity towards the green mussel, Perna viridis. In this study, the toxic effects of BaP (10 µg/L) and DDT (10 µg/L) and their mixture were assessed in green mussel gills with proteomic and metabolomic approaches. Metabolic responses indicated that BaP mainly caused disturbance in osmotic regulation by significantly decrease in branched chain amino acids, dimethylamine and dimethylglycine in gills of male green mussels after exposure for 7 days. DDT mainly caused disturbance in osmotic regulation and energy metabolism by differential alteration of betaine, dimethylamine, dimethylglycine, amino acids, and succinate in gills of male green mussels. However, the mixture of BaP and DDT didn't show obvious metabolite changes. Proteomic analysis showed different protein expression profiles between different treatment groups, which demonstrated that BaP, DDT and their mixture may have different modes of action. Proteomic responses revealed that BaP induced cell apoptosis, disturbance in protein digestion and energy metabolism in gills of green mussels, whereas DDT exposure altered proteins that were associated with oxidative stress, cytoskeleton and cell structure, protein digestion and energy metabolism. However, the mixture of BaP and DDT affected proteins related to the oxidative stress, cytoskeleton and cell structure, protein biosynthesis and modification, energy metabolism, growth and apoptosis. •There exists an antagonistic effect between BaP and DDT.•BaP, DDT and their mixture may have different modes of action.•Proteomics and metabolomics provided an insightful view into the effects of BaP, DDT and the mixture.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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