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Phthalate metabolites in urine samples from Beijing children and correlations with phthalate levels in their handwipes

Gong, M. ; Weschler, C. J. ; Liu, L. ; Shen, H. ; Huang, L. ; Sundell, J. ; Zhang, Y.

Indoor air, 2015-12, Vol.25 (6), p.572-581 [Revista revisada por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Phthalate metabolites in urine samples from Beijing children and correlations with phthalate levels in their handwipes
  • Autor: Gong, M. ; Weschler, C. J. ; Liu, L. ; Shen, H. ; Huang, L. ; Sundell, J. ; Zhang, Y.
  • Materias: Attenuation ; Beijing ; Child ; Child, Preschool ; Children ; Contact transfer ; Dermal absorption ; Estimates ; Exposure pathway ; Female ; Hand ; Humans ; Indoor air quality ; Indoor exposure ; Male ; Metabolites ; Percutaneous absorption ; Phthalates ; Phthalic Acids - adverse effects ; Phthalic Acids - metabolism ; Phthalic Acids - urine ; Plasticizers - adverse effects ; Plasticizers - pharmacokinetics ; Risk Assessment ; Skin - metabolism ; Skin Absorption ; Uptakes ; Urine
  • Es parte de: Indoor air, 2015-12, Vol.25 (6), p.572-581
  • Notas: Tsinghua University's Initiative for Scientific Research - No. 20121088010
    Natural Science Foundation of China - No. 51136002
    Special Fund of the Key Laboratory for Eco Planning & Green Buildings, Ministry of Education - No. 2013B-2
    istex:9434723CB45B08FDA0673BC29E1F25BACB67D4A9
    ark:/67375/WNG-5K0HXPVH-M
    Data S1. Discussion of the metabolite measurements for a second set of aliquots from urine samples. Tables S1-S4. Showing detailed information on Spearman correlation coefficients among phthalates in the same handwipe samples and among phthalate metabolites in the same urine samples, comparison with phthalate levels in handwipes reported in relevant studies, and comparison with phthalate metabolite concentrations in urine from children around the world.
    12th Five-year National Key Technology R&D Program - No. 2012BAJ02B03
    ArticleID:INA12179
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descripción: Little attention has been paid to dermal absorption of phthalates even though modeling suggests that this pathway may contribute meaningfully to total uptake. We have concurrently collected handwipe and urine samples from 39 Beijing children (5–9 years) for the purpose of measuring levels of five phthalates in handwipes, corresponding concentrations of eight of their metabolites in urine, and to subsequently assess the contribution of dermal absorption to total uptake. In summer sampling, DEHP was the most abundant phthalate in handwipes (median: 1130 μg/m2), while MnBP was the most abundant metabolite in urine (median: 232 ng/ml). We found significant associations between the parent phthalate in handwipes and its monoester metabolite in urine for DiBP (r = 0.41, P = 0.01), DnBP (r = 0.50, P = 0.002), BBzP (r = 0.48, P = 0.003), and DEHP (r = 0.36, P = 0.03). Assuming that no dermal uptake occurred under clothing‐covered skin, we estimate that dermal absorption of DiBP, DnBP, BBzP, and DEHP contributed 6.9%, 4.6%, 6.9%, and 3.3%, respectively, to total uptake. Assuming that somewhat attenuated dermal uptake occurred under clothing‐covered skin, these estimates increase to 19%, 14%, 17%, and 10%. The results indicate that absorption from skin surfaces makes a meaningful contribution to total phthalate uptake for children and should be considered in future risk assessments.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglés
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