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Post-Transplant Lymphoproliferative Disorders (PTLD) after Renal Transplantation: Management and Evolution of Seven Cases Among 1002 Renal Transplants in Sao Paulo, Brazil

Colleonf, Gisele W.B. ; Liveira, José Salvador R. ; Borducchi, Davimar M.M. ; Fernandes, Maria Angelina C.F. ; Da Silva, Hélio Tedesco ; Alves, Antonio Correa ; De Franco, Marcello F. ; Kerbauy, JosÉ ; Pestana, José Osmar Medina

Leukemia & lymphoma, 2000-09, Vol.39 (1-2), p.145-150 [Periódico revisado por pares]

United States: Informa UK Ltd

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Título:
Post-Transplant Lymphoproliferative Disorders (PTLD) after Renal Transplantation: Management and Evolution of Seven Cases Among 1002 Renal Transplants in Sao Paulo, Brazil
Autor: Colleonf, Gisele W.B. ; Liveira, José Salvador R. ; Borducchi, Davimar M.M. ; Fernandes, Maria Angelina C.F. ; Da Silva, Hélio Tedesco ; Alves, Antonio Correa ; De Franco, Marcello F. ; Kerbauy, JosÉ ; Pestana, José Osmar Medina
Assuntos: Adult ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - toxicity ; Brazil ; Combined Modality Therapy ; Disease Management ; Epstein-Barr Virus Infections - chemically induced ; Epstein-Barr Virus Infections - complications ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - toxicity ; Kidney Transplantation - adverse effects ; Lymphoma, Non-Hodgkin - chemically induced ; Lymphoma, Non-Hodgkin - etiology ; Lymphoma, Non-Hodgkin - virology ; Lymphoproliferative Disorders - chemically induced ; Lymphoproliferative Disorders - etiology ; Lymphoproliferative Disorders - virology ; Male ; Middle Aged ; PTLD ; renal transplantation ; RNA, Viral - blood ; treatment ; Treatment Outcome
É parte de: Leukemia & lymphoma, 2000-09, Vol.39 (1-2), p.145-150
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: We reported seven cases (0.7%) of PTLD among 1002 renal transplants performed at Renal Transplant Service from Hospital Sao Paulo - Universidade Federal de Sao Paulo/Escola Paulista de Medicina, Sao Paulo, Brazil, between 1976 and 1997. There were three male and four female patients with median age of 37 year-old. According to Ann Arbor staging system there were four localized extra-nodal intermediate-grade NHL, one disseminated low-grade NHL and two polyclonal lymphoid hyperplasia. Four patients received cadaveric, two received related and one received unrelated renal transplant. PTLD occurred after a median latency period of 36 months (ranging from 5 to 84 months). In situ hybridization for EBER1 was performed in five patients and molecular evidence of EBV was found in 3 cases (two DLCL and one lymphoplasmocytoid lymphoma). All patients were treated with immunosuppression withdrawal, four patients received anthracyclin-based chemotherapy for control of localized or systemic clonal disease and three were treated with resection of primary PTLD. Four of seven patients (57%) are in complete remission 11, 20, 25 and 79 months after PTLD onset. One patient lost follow-up and two patients died due to lymphoma relapse, respectively 4 and 10 months after completion of treatment. In conclusion, our experience with this small group of patients showed that: 1) immunosuppression withdrawal is not necessarily associated with loss of renal transplant and can be used as the only treatment for polyclonal PTLD; 2) chemotherapy can simultaneously lead to clonal PTLD remission and periodic immunosuppression, avoiding graft rejection after immunosuppression withdrawal.
Editor: United States: Informa UK Ltd
Idioma: Inglês

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Post-Transplant Lymphoproliferative Disorders (PTLD) after Renal Transplantation: Management and Evolution of Seven Cases Among 1002 Renal Transplants in Sao Paulo, Brazil

Colleonf, Gisele W.B. ; Liveira, José Salvador R. ; Borducchi, Davimar M.M. ; Fernandes, Maria Angelina C.F. ; Da Silva, Hélio Tedesco ; Alves, Antonio Correa ; De Franco, Marcello F. ; Kerbauy, JosÉ ; Pestana, José Osmar Medina

United States: Informa UK Ltd

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