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Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria

Batoni, Giovanna ; Maisetta, Giuseppantonio ; Esin, Semih

Biochimica et biophysica acta, 2016-05, Vol.1858 (5), p.1044-1060 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria
Autor: Batoni, Giovanna ; Maisetta, Giuseppantonio ; Esin, Semih
Assuntos: Animals ; Antibiofilm drugs ; Antimicrobial Cationic Peptides - biosynthesis ; Antimicrobial Cationic Peptides - chemical synthesis ; Antimicrobial Cationic Peptides - pharmacology ; Antimicrobial peptides ; Bacterial Infections - drug therapy ; Bacterial Infections - microbiology ; Bacterial Proteins - antagonists & inhibitors ; Bacterial Proteins - chemistry ; Biofilm ; Biofilm exopolysaccharides ; Biofilm matrix ; Biofilm proteins ; Biofilms - drug effects ; Biofilms - growth & development ; Cell Membrane - chemistry ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Cell Wall - chemistry ; Cell Wall - drug effects ; Cell Wall - metabolism ; Disease Models, Animal ; Drug Design ; Extracellular DNA ; Gram-Negative Bacteria - chemistry ; Gram-Negative Bacteria - drug effects ; Gram-Negative Bacteria - growth & development ; Gram-Positive Bacteria - chemistry ; Gram-Positive Bacteria - drug effects ; Gram-Positive Bacteria - growth & development ; Humans ; Microbial Sensitivity Tests ; Polysaccharides, Bacterial - antagonists & inhibitors ; Polysaccharides, Bacterial - chemistry ; Structure-Activity Relationship
É parte de: Biochimica et biophysica acta, 2016-05, Vol.1858 (5), p.1044-1060
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Biofilm-associated infections represent one of the major threats of modern medicine. Biofilm-forming bacteria are encased in a complex mixture of extracellular polymeric substances (EPS) and acquire properties that render them highly tolerant to conventional antibiotics and host immune response. Therefore, there is a pressing demand of new drugs active against microbial biofilms. In this regard, antimicrobial peptides (AMPs) represent an option taken increasingly in consideration. After dissecting the peculiar biofilm features that may greatly affect the development of new antibiofilm drugs, the present article provides a general overview of the rationale behind the use of AMPs against biofilms of medically relevant bacteria and on the possible mechanisms of AMP-antibiofilm activity. An analysis of the interactions of AMPs with biofilm components, especially those constituting the EPS, and the obstacles and/or opportunities that may arise from such interactions in the development of new AMP-based antibiofilm strategies is also presented and discussed. This article is part of a Special Issue entitled: Antimicrobial Peptides edited by Karl Lohner and Kai Hilpert. [Display omitted] •Biofilm-associated infections are one of the major threats of modern medicine.•AMPs may represent a promising therapeutic approach for biofilm-associated infections.•AMP-activity may rely on bactericidal effect or interference with biofilm lifestyle.•Interaction with polymers of biofilm matrix may hamper AMPs' antibiofilm activity.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria

Batoni, Giovanna ; Maisetta, Giuseppantonio ; Esin, Semih

Netherlands: Elsevier B.V

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