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The effects of combined human parathyroid hormone (1–34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenic rats femurs

Tao, Zhou-Shan ; Zhou, Wan-Shu ; Bai, Bing-li ; Cui, Wei ; Lv, Yang-Xun ; Yu, Xian-Bin ; Huang, Zheng-Liang ; Tu, Kai-kai ; Zhou, Qiang ; Sun, Tao ; Li, Hang ; Yang, Lei

Journal of materials science. Materials in medicine, 2016-03, Vol.27 (3), p.43-8, Article 43 [Periódico revisado por pares]

New York: Springer US

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Título:
The effects of combined human parathyroid hormone (1–34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenic rats femurs
Autor: Tao, Zhou-Shan ; Zhou, Wan-Shu ; Bai, Bing-li ; Cui, Wei ; Lv, Yang-Xun ; Yu, Xian-Bin ; Huang, Zheng-Liang ; Tu, Kai-kai ; Zhou, Qiang ; Sun, Tao ; Li, Hang ; Yang, Lei
Assuntos: Animals ; Arthroplasty, Replacement, Hip - instrumentation ; Biocompatibility ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bone Density Conservation Agents - pharmacology ; Bone Diseases, Metabolic - pathology ; Bone Regeneration - drug effects ; Bones ; Ceramics ; Chemistry and Materials Science ; Clinical Applications of Biomaterials ; Coated Materials, Biocompatible - pharmacology ; Composites ; Dietary Proteins - administration & dosage ; Endocrine system ; Female ; Femur - pathology ; Glass ; Healing ; Hip Prosthesis ; Hormones ; Hydroxyapatite ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Implants, Experimental ; Materials Science ; Natural Materials ; Osseointegration - drug effects ; Parathyroid Hormone - administration & dosage ; Parathyroid Hormone - pharmacology ; Polymer Sciences ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Regenerative Medicine/Tissue Engineering ; SIM ; Simvastatin - administration & dosage ; Simvastatin - pharmacology ; Surfaces and Interfaces ; Surgical implants ; Thin Films ; Titanium
É parte de: Journal of materials science. Materials in medicine, 2016-03, Vol.27 (3), p.43-8, Article 43
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The effect of human parathyroid hormone 1–34 (PTH) and simvastatin (SIM) alone could promote bone healing in osteoporotic implant fixation, but there are no reports about the combined use of PTH and SIM for promotion of bone healing around implant in osteoporotic settings. This study aims to investigate effects of PTH + SIM on implant stabilization in osteopenic rats. Fourteen weeks after chronically fed a low protein diet, osteopenic rats randomly received implants. Subsequently, the animals were randomly divided into four groups: Control, SIM, PTH and PTH + SIM. Then all rats from groups PTH, SIM and PTH + SIM received PTH (40 μg/kg, three times a week), SIM (25 mg/kg, daily), or both for 12 weeks. The results of our study indicated that all treatments promoted bone healing around implant compared to Control, but PTH + SIM treatment showed significantly stronger effects than PTH or SIM alone in histological, micro-CT, and biomechanical tests. The results indicated additive effects of PTH and SIM on implant fixation in osteoporotic rats.
Editor: New York: Springer US
Idioma: Inglês

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The effects of combined human parathyroid hormone (1–34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenic rats femurs

Tao, Zhou-Shan ; Zhou, Wan-Shu ; Bai, Bing-li ; Cui, Wei ; Lv, Yang-Xun ; Yu, Xian-Bin ; Huang, Zheng-Liang ; Tu, Kai-kai ; Zhou, Qiang ; Sun, Tao ; Li, Hang ; Yang, Lei

New York: Springer US

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