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Activation of NK cells is associated with HIV‐1 disease progression

Kuri‐Cervantes, Leticia ; Oca, Gonzalo Salgado‐Montes ; Ávila‐Ríos, Santiago ; Hernández‐Juan, Ramón ; Reyes‐Terán, Gustavo

Journal of leukocyte biology, 2014-07, Vol.96 (1), p.7-16 [Periódico revisado por pares]

United States

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Título:
Activation of NK cells is associated with HIV‐1 disease progression
Autor: Kuri‐Cervantes, Leticia ; Oca, Gonzalo Salgado‐Montes ; Ávila‐Ríos, Santiago ; Hernández‐Juan, Ramón ; Reyes‐Terán, Gustavo
Assuntos: Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - pathology ; ADP-ribosyl Cyclase 1 - immunology ; ADP-ribosyl Cyclase 1 - metabolism ; Adult ; AIDS ; CD38 ; CD4 Lymphocyte Count ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; CD8-Positive T-Lymphocytes - pathology ; controllers ; Disease Progression ; elite controllers ; Female ; HIV-1 - immunology ; HLA-DR Antigens - immunology ; HLA-DR Antigens - metabolism ; HLA‐DR ; Human immunodeficiency virus 1 ; Humans ; immune activation ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Killer Cells, Natural - pathology ; Lymphocyte Activation ; Male ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - metabolism ; Viremia - immunology ; Viremia - metabolism
É parte de: Journal of leukocyte biology, 2014-07, Vol.96 (1), p.7-16
Notas: ObjectType-Article-2
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Descrição: CD38 expression on CD56dimCD16+ NK cells is strongly associated with HIV‐1 disease progression, and affected by the individualˈs immunologic state. The main predictor of HIV‐1 disease progression is CD8+ T cell activation, characterized by elevated expression of CD38 and HLA‐DR. NK cells are also activated in viremic HIV‐1‐infected individuals. However, the relationship between NK cell activation and HIV‐1 disease progression remains undefined. We characterized NK cell activation and its association with disease progression in treatment of naive HIV‐1‐infected individuals, who naturally maintained low/undetectable viremia (elite and viremic controllers), compared with progressors and AIDS subjects, and treated individuals. Our results show that CD38 expression on NK cells, predominantly in the cytotoxic CD56dimCD16+ subset, is associated with HIV‐1 disease progression (CD4+ T cell count and pVL), T cell activation (percentage of CD38+HLA‐DR+ T cells), sCD14, inflammation, and innate immune activation. Moreover, NK cell activation is increased in HIV‐1‐infected subjects progressing to AIDS but not in elite and viremic controllers. ART partially reduces the proportion of activated NK cells. Furthermore, our results show that individuals, who naturally control viremia, maintain low levels of innate immune activation similar to those of uninfected controls.
Editor: United States
Idioma: Inglês

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Activation of NK cells is associated with HIV‐1 disease progression

Kuri‐Cervantes, Leticia ; Oca, Gonzalo Salgado‐Montes ; Ávila‐Ríos, Santiago ; Hernández‐Juan, Ramón ; Reyes‐Terán, Gustavo

United States

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