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Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma

Dixon, Peter R. ; Au, Michael ; Hosni, Ali ; Perez-Ordonez, Bayardo ; Weinreb, Ilan ; Xu, Wei ; Song, Yuyao ; Huang, Shao Hui ; O'Sullivan, Brian ; Goldstein, David P. ; de Almeida, John R.

Head & neck, 2016-09, Vol.38 (9), p.1347-1353 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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Título:
Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma
Autor: Dixon, Peter R. ; Au, Michael ; Hosni, Ali ; Perez-Ordonez, Bayardo ; Weinreb, Ilan ; Xu, Wei ; Song, Yuyao ; Huang, Shao Hui ; O'Sullivan, Brian ; Goldstein, David P. ; de Almeida, John R.
Assuntos: Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Cancer Care Facilities ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Cyclin-Dependent Kinase Inhibitor p16 - metabolism ; Female ; head and neck neoplasms ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; human papilloma virus ; Human papillomavirus ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasms, Unknown Primary - mortality ; Neoplasms, Unknown Primary - pathology ; Neoplasms, Unknown Primary - therapy ; Ontario ; p16 ; Papillomaviridae - isolation & purification ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Registries ; Retrospective Studies ; Risk Assessment ; Smoking - adverse effects ; Smoking - mortality ; squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck ; Survival Analysis ; unknown primary neoplasms
É parte de: Head & neck, 2016-09, Vol.38 (9), p.1347-1353
Notas: ArticleID:HED24441
ark:/67375/WNG-2Q1BWKCZ-F
istex:906141546112479E05CBE920B519BB340247D6CF
A portion of this manuscript was presented orally at the International Federation of Head and Neck Oncologic Societies Fifth World Congress, American Head and Neck Society Annual Meeting, New York, NY, July 29, 2014.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background The prognostic significance of human papillomavirus (HPV) in the context of head and neck squamous cell carcinoma (HNSCC) of cancer of unknown primary (CUP) origin is unclear. Methods Patients treated for CUP at the Princess Margaret Cancer Centre between 2001 and 2013 were stratified by p16 status and retrospectively reviewed. Results Of the 73 patients included, those with p16‐positive tumors (63%) had less advanced nodal status (N1–N2b; 52% vs 89%; p = .035) and less aggressive treatment. Patients with p16‐positive tumors had improved 3‐year disease‐free survival (DFS; 79% vs 56%; p = .012) independent of nodal status and treatment in multivariable analysis (hazard ratio [HR] = 0.27; 95% confidence interval [CI] = 0.08–0.95). Conclusion Among patients with CUP, p16‐positive status is an independent predictor of DFS but not overall survival (OS). © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38: 1347–1353, 2016
Editor: United States: Blackwell Publishing Ltd
Idioma: Inglês

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Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma

Dixon, Peter R. ; Au, Michael ; Hosni, Ali ; Perez-Ordonez, Bayardo ; Weinreb, Ilan ; Xu, Wei ; Song, Yuyao ; Huang, Shao Hui ; O'Sullivan, Brian ; Goldstein, David P. ; de Almeida, John R.

United States: Blackwell Publishing Ltd

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