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Characterization and biological evaluation of the introduction of PLGA into biosilicate

Fernandes, K R ; Magri, A M P ; Kido, H W ; Ueno, F ; Assis, L ; Fernandes, K P S ; Mesquita-Ferrari, R A ; Martins, V C ; Plepis, A M ; Zanotto, E D ; Peitl, O ; Ribeiro, D ; van den Beucken, J J ; Renno, A C M

Journal of biomedical materials research. Part B, Applied biomaterials, 2017-07, Vol.105 (5), p.1063-1074 [Revista revisada por pares]

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Characterization and biological evaluation of the introduction of PLGA into biosilicate
Autor: Fernandes, K R ; Magri, A M P ; Kido, H W ; Ueno, F ; Assis, L ; Fernandes, K P S ; Mesquita-Ferrari, R A ; Martins, V C ; Plepis, A M ; Zanotto, E D ; Peitl, O ; Ribeiro, D ; van den Beucken, J J ; Renno, A C M
Materias: Animals ; Biocompatibility ; Biomaterials ; Biomedical materials ; Bone growth ; Bone healing ; Cell Line ; Cell Survival - drug effects ; Fibroblasts ; Fibroblasts - cytology ; Fibroblasts - pathology ; Granulation ; Histopathology ; Hydrogen-Ion Concentration ; Immunohistochemistry ; Implantation ; In vitro methods and tests ; In vivo methods and tests ; Incubation ; Lactic Acid - chemistry ; Lactic Acid - pharmacology ; Materials research ; Materials science ; Materials Testing ; Mice ; Morphology ; Osteoblasts - metabolism ; Osteoblasts - pathology ; Osteogenesis ; Osteogenesis - drug effects ; pH effects ; Physical characteristics ; Polyglycolic Acid - chemistry ; Polyglycolic Acid - pharmacology ; Polylactide-co-glycolide ; Pore formation ; Rats ; Silicates - chemistry ; Silicates - pharmacology ; Silicic acid ; Surgical implants ; Tibia - metabolism ; Tibia - pathology ; Tibial Fractures - metabolism ; Tibial Fractures - pathology ; Tibial Fractures - therapy ; TRANCE protein ; X-ray diffraction
Es parte de: Journal of biomedical materials research. Part B, Applied biomaterials, 2017-07, Vol.105 (5), p.1063-1074
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
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Descripción: The aims of this study were to characterize different BS/PLGA composites for their physicochemical and morphological characteristics and evaluate the in vitro and in vivo biological performance. The physicochemical and morphological modifications were analyzed by pH, mass loss, XRD, setting time, and SEM. For in vitro analysis, the osteoblast and fibroblast viability was evaluated. For in vivo evaluations, histopathology and immunohistochemistry were performed in a tibial defect in rats. After incubation, all composites presented lower values in pH and mass loss over time. Moreover, XRD and SEM analysis confirmed that the composites degraded over time. Additionally, pore formation was observed by SEM analysis after incubation mainly in BS/PLGA groups. BS/PLGA showed significantly increased in osteoblast viability 24 h. Moreover, BS/PLGA composites demonstrated an increase in fibroblast viability in all periods analyzed when compared to BS. In the in vivo study, after 2 and 6 weeks of implantation of biomaterials, histopathological findings revealed that the BS/PLGA composites degrades over time, mainly at periphery. Moreover, can be observed the presence of granulation tissue, bone formation, Runx-2, and RANKL immunoexpression in all groups. In conclusion, BS/PLGA composites present appropriate physicochemical characteristics, stimulate the cellular viability, and enhance the bone repair in vivo. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1063-1074, 2017.
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Characterization and biological evaluation of the introduction of PLGA into biosilicate

Fernandes, K R ; Magri, A M P ; Kido, H W ; Ueno, F ; Assis, L ; Fernandes, K P S ; Mesquita-Ferrari, R A ; Martins, V C ; Plepis, A M ; Zanotto, E D ; Peitl, O ; Ribeiro, D ; van den Beucken, J J ; Renno, A C M

United States: Wiley Subscription Services, Inc

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