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The effect of dental bleaching on pulpal tissue response in a diabetic animal model

Cintra, L. T. A. ; Ferreira, L. L. ; Benetti, F. ; Gastélum, A. A. ; Gomes‐Filho, J. E. ; Ervolino, E. ; Briso, A. L. F.

International endodontic journal, 2017-08, Vol.50 (8), p.790-798 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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  • Título:
    The effect of dental bleaching on pulpal tissue response in a diabetic animal model
  • Autor: Cintra, L. T. A. ; Ferreira, L. L. ; Benetti, F. ; Gastélum, A. A. ; Gomes‐Filho, J. E. ; Ervolino, E. ; Briso, A. L. F.
  • Assuntos: Animals ; Bleaching ; Collagen ; dental bleaching ; Dental pulp ; Dental Pulp Cavity - pathology ; Dentistry ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - physiopathology ; Endodontics ; Hydrogen peroxide ; Hydrogen Peroxide - adverse effects ; Inflammation ; inflammatory response ; Male ; Maxilla ; Molars ; Necrosis - chemically induced ; Pulpitis - chemically induced ; Rats, Wistar ; reactionary dentine ; Rodents ; Teeth ; Tooth Bleaching Agents - adverse effects
  • É parte de: International endodontic journal, 2017-08, Vol.50 (8), p.790-798
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Aim To evaluate pulpal tissue response after dental bleaching in normal and alloxan‐induced diabetic rats. Methodology Twenty‐eight rats were divided into two groups of normoglycaemic and diabetic rats (n = 14). Diabetes mellitus (DM) was induced with alloxan. After DM confirmation, all rats were anaesthetized and dental bleaching was performed with 35% hydrogen peroxide (H2O2) on the right maxillary molars for 30 min. Left molars were used as controls. Bleaching resulted in four hemimaxillae groups: normoglycaemic (N), N‐bleached (NBle), diabetic (D) and D‐bleached (DBle). After 2 or 30 days, the animals were euthanized and the hemimaxillae were removed, processed for histopathological analysis and stained with haematoxylin–eosin (HE), Masson's trichrome (MT) and picrosirius red (PSR). Results obtained within animals (normoglycaemic or diabetic rats) were submitted to Wilcoxon or paired t‐tests, and between animal (normoglycaemic and diabetic rats), to Mann–Whitney test or t‐tests. Results At 2 days, the NBle group had a mild inflammatory infiltration in the pulpal tissue, whilst the DBle had severe inflammation or necrosis (P < 0.05). At 30 days, no inflammation was present. However, a significant difference in pulp chamber area reduction by reactionary dentine deposition was found between the NBle and DBle groups (P < 0.05). At 2 days, fewer immature collagen fibres and more mature collagen fibres were noted in the NBle, D and DBle groups; this was significantly different when compared to the N group (P < 0.05). At 30 days, significantly fewer immature collagen fibres and more mature collagen fibres were noted in NBle compared with DBle group (P < 0.05). Conclusions The inflammatory tissue response in rats’ teeth after dental bleaching was greater in diabetic rats. Additionally, the increase in reactionary dentine deposition and mature collagen fibres observed in diabetic rats needs further evaluation to confirm the present results.
  • Editor: England: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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