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Epigenetic countermarks in mitotic chromosome condensation

van Wely, Karel H. M. ; Mora Gallardo, Carmen ; Vann, Kendra R. ; Kutateladze, Tatiana G.

Nucleus (Austin, Tex.), 2017-03, Vol.8 (2), p.144-149 [Periódico revisado por pares]

United States: Taylor & Francis

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Título:
Epigenetic countermarks in mitotic chromosome condensation
Autor: van Wely, Karel H. M. ; Mora Gallardo, Carmen ; Vann, Kendra R. ; Kutateladze, Tatiana G.
Assuntos: Aurora B ; Chromatin - chemistry ; Chromatin - metabolism ; chromatin condensation ; Chromosome Segregation - genetics ; Epigenesis, Genetic ; epigenetics ; Extra View ; Haspin ; histone ; histone reader ; Humans ; mitosis ; Mitosis - genetics ; phoshpo/methyl switch
É parte de: Nucleus (Austin, Tex.), 2017-03, Vol.8 (2), p.144-149
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Mitosis in metazoans is characterized by abundant phosphorylation of histone H3 and involves the recruitment of condensin complexes to chromatin. The relationship between the 2 phenomena and their respective contributions to chromosome condensation in vivo remain poorly understood. Recent studies have shown that H3T3 phosphorylation decreases binding of histone readers to methylated H3K4 in vitro and is essential to displace the corresponding proteins from mitotic chromatin in vivo. Together with previous observations, these data provide further evidence for a role of mitotic histone H3 phosphorylation in blocking transcriptional programs or preserving the 'memory' PTMs. Mitotic protein exclusion can also have a role in depopulating the chromatin template for subsequent condensin loading. H3 phosphorylation thus serves as an integral step in the condensation of chromosome arms.
Editor: United States: Taylor & Francis
Idioma: Inglês

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Epigenetic countermarks in mitotic chromosome condensation

van Wely, Karel H. M. ; Mora Gallardo, Carmen ; Vann, Kendra R. ; Kutateladze, Tatiana G.

United States: Taylor & Francis

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