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3D structural complexity analysis of cerebellum in Chiari malformation type I

Akar, Engin ; Kara, Sadık ; Akdemir, Hidayet ; Kırış, Adem

Medical & biological engineering & computing, 2017-12, Vol.55 (12), p.2169-2182 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
3D structural complexity analysis of cerebellum in Chiari malformation type I
Autor: Akar, Engin ; Kara, Sadık ; Akdemir, Hidayet ; Kırış, Adem
Assuntos: Adolescent ; Adult ; Arnold-Chiari Malformation - diagnostic imaging ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Brain ; Cerebellum ; Cerebellum - diagnostic imaging ; Cerebrospinal fluid ; Complexity ; Computer Applications ; Congenital defects ; Developmental disabilities ; Female ; Fractal analysis ; Fractals ; Human Physiology ; Humans ; Imaging ; Imaging, Three-Dimensional - methods ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Neural tube defects ; Original Article ; Patients ; Radiology ; Statistical analysis ; Substantia alba ; Substantia grisea ; Young Adult
É parte de: Medical & biological engineering & computing, 2017-12, Vol.55 (12), p.2169-2182
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Chiari malformation type I (CM-I), described by a descent of the cerebellar tonsils, is assumed to be a neurological developmental disorder. The aim of the present study was to investigate morphological variance in cerebellar sub-structures, including gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF), using magnetic resonance (MR) images with three-dimensional (3D) fractal dimension (FD) analysis in patients with CM-I. MRI data of 16 patients and 15 control subjects were obtained, and structural complexity analyses were performed using a box-counting FD algorithm. Results showed that patients with CM-I had significantly reduced FD values for WM and CSF in comparison with controls, and statistically significant differences in cerebellar GM and CSF volumes between patients and controls were found. Moreover, a significant difference was not found between the WM volumes. This may suggest that there are changes in structural complexity in WM even when its volume is unaffected. We conclude that the findings of this preliminary study indicate the possibility of using FD analysis to understand the pathophysiology of CM-I in patients.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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3D structural complexity analysis of cerebellum in Chiari malformation type I

Akar, Engin ; Kara, Sadık ; Akdemir, Hidayet ; Kırış, Adem

Berlin/Heidelberg: Springer Berlin Heidelberg

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