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Blink R1 latency utility in diagnosis and treatment assessment of polyradiculoneuropathy‐organomegaly‐endocrinopathy‐monoclonal protein‐skin changes and chronic inflammatory demyelinating polyradiculoneuropathy

Wang, Wei ; Litchy, William J. ; Mauermann, Michelle L. ; Dyck, P. James B. ; Dispenzieri, Angela ; Mandrekar, Jay ; Dyck, Peter J. ; Klein, Christopher J.

Muscle & nerve, 2018-01, Vol.57 (1), p.E8-E13 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Blink R1 latency utility in diagnosis and treatment assessment of polyradiculoneuropathy‐organomegaly‐endocrinopathy‐monoclonal protein‐skin changes and chronic inflammatory demyelinating polyradiculoneuropathy
Autor: Wang, Wei ; Litchy, William J. ; Mauermann, Michelle L. ; Dyck, P. James B. ; Dispenzieri, Angela ; Mandrekar, Jay ; Dyck, Peter J. ; Klein, Christopher J.
Assuntos: Adult ; Blink reflex ; Blinking ; CIDP ; Demyelination ; Diagnosis, Differential ; Endocrine disorders ; Female ; Follow-Up Studies ; Humans ; Inflammation ; Latency ; Male ; Medical diagnosis ; Middle Aged ; Muscles ; Nerve conduction ; nerve conduction study ; Nervous System Diseases - etiology ; Nervous System Diseases - physiopathology ; Neural Conduction ; Neurologic Examination ; Neuropathy ; Patients ; POEMS Syndrome - diagnosis ; POEMS Syndrome - physiopathology ; POEMS Syndrome - therapy ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - diagnosis ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - physiopathology ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - therapy ; Prolongation ; Reproducibility of Results ; Retrospective Studies ; Skin ; Stem Cell Transplantation ; Treatment Outcome ; Ulnar Nerve - physiopathology
É parte de: Muscle & nerve, 2018-01, Vol.57 (1), p.E8-E13
Notas: with an associated stipend; Dr Mauermann is a pharmaceutical consultant for IONIS; Drs Wang, James Dyck, Mandrekar, and Klein report no disclosures.
Conflicts of Interest
Diabetes
Funding
Drs Litchy and Dispenzieri are pharmaceutical study consultants for IONIS and Alnylam; Dr Peter Dyck is a pharmaceutical study consultant for IONIS and Alnylam and Associate Editor of
This work was supported by the Mayo Foundation and China Japan Friendship Hospital.
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Descrição: ABSTRACT Introduction: In polyradiculoneuropathy‐organomegaly‐endocrinopathy‐monoclonal protein‐skin changes (POEMS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), limb nerve conduction studies (NCSs) are limited in identifying demyelination and in detecting treatment effects in severely affected patients. Blink R1 latency may improve these assessments. Methods: POEMS and CIDP patients who had undergone NCS and blink reflex were identified. Correlations among R1 latency, limb NCS, and neuropathy impairment scores (NIS) were compared. Results: Among 182 patients (124 POEMS, 58 CIDP) who were identified, R1 prolongation (>13 ms) occurred in 64.3% (65.3% POEMS, 62.1% CIDP). R1 prolongation correlated with more severely affected NCS in both POEMS (ulnar CMAP 2.6 mV vs. 4.5 mV, P = 0.001) and CIDP (2.0 mV vs. 6.1 mV, P < 0.001). In severely affected patients (ulnar CMAP ≤0.5 mV [10%:18/182]), R1 (>13 ms) helped establish demyelination. In 31 patients (16 POEMS, 15 CIDP), the R1 latency changes were concordant with NIS changes in 94% of patients with POEMS and 60% of patients with CIDP. Discussion: Blink R1 latencies are valuable in defining demyelination and detecting improvement in severely affected POEMS and CIDP patients. Muscle Nerve 57: E8–E13, 2018
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Blink R1 latency utility in diagnosis and treatment assessment of polyradiculoneuropathy‐organomegaly‐endocrinopathy‐monoclonal protein‐skin changes and chronic inflammatory demyelinating polyradiculoneuropathy

Wang, Wei ; Litchy, William J. ; Mauermann, Michelle L. ; Dyck, P. James B. ; Dispenzieri, Angela ; Mandrekar, Jay ; Dyck, Peter J. ; Klein, Christopher J.

United States: Wiley Subscription Services, Inc

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