Idioma:

Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis

Dos Santos, E V W ; Alves, L N R ; Louro, I D

Genetics and molecular research, 2017-07, Vol.16 (3), p.1 [Periódico revisado por pares]

Brazil: Fundacao de Pesquisas Cientificas de Ribeirao Preto

Texto completo disponível

Citações Citado por

Enviar para

Título:
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis
Autor: Dos Santos, E V W ; Alves, L N R ; Louro, I D
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aromatase ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinogenesis ; Estrogen receptors ; Estrogens ; Etiology ; Female ; Genotypes ; Glutathione S-Transferase pi - genetics ; Glutathione transferase ; Heterozygosity ; Humans ; Loss of Heterozygosity ; Medical prognosis ; Metabolism ; Microsatellite instability ; Microsatellite Repeats ; Middle Aged ; Ovarian cancer ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - pathology ; Polymerase chain reaction ; Polymorphism, Genetic ; Population studies ; Progesterone ; Restriction fragment length polymorphism ; Steroid 17-alpha-Hydroxylase - genetics ; Steroids - metabolism ; Tumors
É parte de: Genetics and molecular research, 2017-07, Vol.16 (3), p.1
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instability) and LOH (loss of heterozygosity) in AR, ERβ and CYP19 genes in women from Espírito Santo State, Brazil. The study population consisted of 107 female breast and 24 ovarian tumors. GSTP1 and CYP17 polymorphisms were detected by polymerase chain reaction (PCR) amplification followed by restriction fragment length polymorphism (RFLP) analysis while MSI and LOH were analyzed by PCR. GSTP1 and CYP17 polymorphisms alone were not associated with an increased risk for breast or ovarian tumors. However, when combined with MSI/LOH in AR, ERβ and CYP19 genes, we were able to detect significant associations with the GSTP1 wild-type genotype in PR (progesterone receptor) negative breast cancers or the CYP17 wild-type genotype in ER (estrogen receptor) and PR-negative breast tumors. No associations with ovarian tumors were detected. Our results suggest that wild-type GSTP1 or CYP17 genes when combined with LOH/MSI in steroid metabolism genes may play a role in ER and/or PR negative breast cancers. These data support the hypothesis that genes related to steroid metabolism are important in the characterization of breast cancer and that the analysis of single polymorphisms may not be sufficient.
Editor: Brazil: Fundacao de Pesquisas Cientificas de Ribeirao Preto
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis

Dos Santos, E V W ; Alves, L N R ; Louro, I D

Brazil: Fundacao de Pesquisas Cientificas de Ribeirao Preto

Buscando em bases de dados remotas. Favor aguardar.