Idioma:

Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

Achatz, Maria Isabel ; Porter, Christopher C ; Brugières, Laurence ; Druker, Harriet ; Frebourg, Thierry ; Foulkes, William D ; Kratz, Christian P ; Kuiper, Roland P ; Hansford, Jordan R ; Hernandez, Hector Salvador ; Nathanson, Katherine L ; Kohlmann, Wendy K ; Doros, Leslie ; Onel, Kenan ; Schneider, Kami Wolfe ; Scollon, Sarah R ; Tabori, Uri ; Tomlinson, Gail E ; Evans, D Gareth R ; Plon, Sharon E

Clinical cancer research, 2017-07, Vol.23 (13), p.e107-e114 [Periódico revisado por pares]

United States: American Association for Cancer Research Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood
Autor: Achatz, Maria Isabel ; Porter, Christopher C ; Brugières, Laurence ; Druker, Harriet ; Frebourg, Thierry ; Foulkes, William D ; Kratz, Christian P ; Kuiper, Roland P ; Hansford, Jordan R ; Hernandez, Hector Salvador ; Nathanson, Katherine L ; Kohlmann, Wendy K ; Doros, Leslie ; Onel, Kenan ; Schneider, Kami Wolfe ; Scollon, Sarah R ; Tabori, Uri ; Tomlinson, Gail E ; Evans, D Gareth R ; Plon, Sharon E
Assuntos: Adenomatous polyposis coli ; Adenomatous Polyposis Coli - diagnosis ; Adenomatous Polyposis Coli - epidemiology ; Adenomatous Polyposis Coli - genetics ; Cancer ; Cancer screening ; Child ; Children ; Disorders ; Early Detection of Cancer ; Gastrointestinal Neoplasms - diagnosis ; Gastrointestinal Neoplasms - epidemiology ; Gastrointestinal Neoplasms - genetics ; Genetic Predisposition to Disease ; Genetic screening ; Genetic Testing ; Hamartoma Syndrome, Multiple - diagnosis ; Hamartoma Syndrome, Multiple - epidemiology ; Hamartoma Syndrome, Multiple - genetics ; Health risks ; Humans ; Literature reviews ; LKB1 protein ; Management ; Medical screening ; Mismatch repair ; Neoplasia ; Neoplasms ; Pediatrics ; Peutz-Jeghers Syndrome - diagnosis ; Peutz-Jeghers Syndrome - epidemiology ; Peutz-Jeghers Syndrome - genetics ; Polyposis coli ; PTEN protein ; Repair ; Risk management ; Smad4 protein ; Surveillance
É parte de: Clinical cancer research, 2017-07, Vol.23 (13), p.e107-e114
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
Descrição: Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in which international experts in care of children with a hereditary risk of cancer met to define surveillance strategies and management of children with cancer predisposition syndromes. In this article, we review the current literature in polyposis syndromes that can be diagnosed in childhood and may be associated with an increased incidence of gastrointestinal neoplasms and other cancer types. These disorders include adenomatous polyposis syndromes ( and ), juvenile polyposis coli ( and ), Peutz-Jeghers Syndrome ( / ), and PTEN hamartoma tumor syndrome (PHTS; ), which can present with a more limited juvenile polyposis phenotype. Herein, the panel of experts provides recommendations for clinical diagnosis, approach to genetic testing, and focus on cancer surveillance recommendations when appropriate during the pediatric period. We also review current controversies on genetic evaluation of patients with hepatoblastoma and indications for surveillance for this tumor. Childhood cancer risks and surveillance associated with disorders involving the mismatch repair genes, including Lynch syndrome and constitutional mismatch repair deficiency (CMMRD), are discussed elsewhere in this series. .
Editor: United States: American Association for Cancer Research Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

United States: American Association for Cancer Research Inc

Buscando em bases de dados remotas. Favor aguardar.