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Randomized clinical trial of hepatic resection versus radiofrequency ablation for early‐stage hepatocellular carcinoma

Ng, K. K. C. ; Chok, K. S. H. ; Chan, A. C. Y. ; Cheung, T. T. ; Wong, T. C. L. ; Fung, J. Y. Y. ; Yuen, J. ; Poon, R. T. P. ; Fan, S. T. ; Lo, C. M.

British journal of surgery, 2017-12, Vol.104 (13), p.1775-1784 [Peer Reviewed Journal]

Chichester, UK: John Wiley & Sons, Ltd

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Title:
Randomized clinical trial of hepatic resection versus radiofrequency ablation for early‐stage hepatocellular carcinoma
Author: Ng, K. K. C. ; Chok, K. S. H. ; Chan, A. C. Y. ; Cheung, T. T. ; Wong, T. C. L. ; Fung, J. Y. Y. ; Yuen, J. ; Poon, R. T. P. ; Fan, S. T. ; Lo, C. M.
Subjects: Adult ; Aged ; Aged, 80 and over ; Blood Loss, Surgical ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Catheter Ablation ; Clinical trials ; Coloring Agents ; Disease-Free Survival ; Female ; Hepatectomy ; Hepatitis C - complications ; Hong Kong - epidemiology ; Humans ; Indocyanine Green ; Length of Stay ; Liver cancer ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Prognosis ; Young Adult
Is Part Of: British journal of surgery, 2017-12, Vol.104 (13), p.1775-1784
Notes: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
Description: Background Hepatic resection and radiofrequency ablation (RFA) are treatment options for early‐stage hepatocellular carcinoma (HCC). Whether tumour recurrence and long‐term survival favour either treatment has not been established. This randomized trial aimed to test the hypothesis that RFA is superior to hepatic resection in terms of lower tumour recurrence rate and better long‐term survival. Methods Patients with early‐stage HCC (solitary tumour no larger than 5 cm; or no more than 3 tumours, each 3 cm or smaller) were randomized into hepatic resection and RFA groups. Demographic and clinical characteristics, and short‐ and long‐term outcome measures were compared between groups. Primary and secondary outcome measures were overall tumour recurrence and survival respectively. Results Clinicopathological data were similar in the two groups, which each contained 109 patients. The RFA group had a shorter treatment duration, less blood loss and shorter hospital stay than the resection group. Mortality and morbidity rates were similar in the two groups. The overall tumour recurrence rate was similar in the resection and RFA groups (71·3 versus 81·7 per cent respectively). The 1‐, 3‐, 5‐ and 10‐year overall survival rates were 94·5, 80·6, 66·5 and 47·6 per cent respectively in the resection group, compared with 95·4, 82·3, 66·4 and 41·8 per cent in the RFA group (P = 0·531). Corresponding disease‐free survival rates were 74·1, 50·9, 41·5 and 31·9 per cent in the resection group, and 70·6, 46·6, 33·6 and 18·6 per cent in the RFA group (P = 0·072). Conclusion RFA for early‐stage HCC is not superior to hepatic resection, in terms of tumour recurrence, overall survival and disease‐free survival. Registration number: HKUCTR‐10 (http://www.hkuctr.com). Radiofrequency ablation is not superior
Publisher: Chichester, UK: John Wiley & Sons, Ltd
Language: English

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Randomized clinical trial of hepatic resection versus radiofrequency ablation for early‐stage hepatocellular carcinoma

Ng, K. K. C. ; Chok, K. S. H. ; Chan, A. C. Y. ; Cheung, T. T. ; Wong, T. C. L. ; Fung, J. Y. Y. ; Yuen, J. ; Poon, R. T. P. ; Fan, S. T. ; Lo, C. M.

Chichester, UK: John Wiley & Sons, Ltd

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