Idioma:

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

KENSLER, Thomas W ; WAKABAYASHI, Nobunao ; BISWAL, Shyam

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.89-116 [Revista revisada por pares]

Palo Alto, CA: Annual Reviews

Texto completo disponible

Citas Citado por

Acciones

Título:
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
Autor: KENSLER, Thomas W ; WAKABAYASHI, Nobunao ; BISWAL, Shyam
Materias: Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Antioxidants - physiology ; Biological and medical sciences ; Cell Survival ; Cytoprotection ; Cytoskeletal Proteins - genetics ; Cytoskeletal Proteins - metabolism ; Environmental Exposure ; Gene Expression ; General aspects. Methods ; Kelch-Like ECH-Associated Protein 1 ; Medical sciences ; Mice ; Mice, Knockout ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Oxidative Stress ; Toxicology
Es parte de: Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.89-116
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descripción: Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from endogenous and exogenous stresses. The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway. These mice are more sensitive to the hepatic, pulmonary, ovarian, and neurotoxic consequences of acute exposures to environmental agents and drugs, inflammatory stresses, as well as chronic exposures to cigarette smoke and other carcinogens. Under quiescent conditions, the transcription factor Nrf2 interacts with the actin-anchored protein Keap1, largely localized in the cytoplasm. This quenching interaction maintains low basal expression of Nrf2-regulated genes. However, upon recognition of chemical signals imparted by oxidative and electrophilic molecules, Nrf2 is released from Keap1, escapes proteasomal degradation, translocates to the nucleus, and transactivates the expression of several dozen cytoprotective genes that enhance cell survival. This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.
Editor: Palo Alto, CA: Annual Reviews
Idioma: Inglés

Enlaces

Volver a la lista de resultados

Anterior Resultado 10 Siguiente Ir a la siguiente página

Realización: Logos de Redes Sociales:

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

KENSLER, Thomas W ; WAKABAYASHI, Nobunao ; BISWAL, Shyam

Palo Alto, CA: Annual Reviews

Buscando en bases de datos remotas, por favor espere