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Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca

Barreto, S.A. ; Chaguri, L.C.A.G. ; Prezoto, B.C. ; Lebrun, I.

Comparative biochemistry and physiology. Toxicology & pharmacology, 2009-05, Vol.149 (4), p.552-558 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca
Autor: Barreto, S.A. ; Chaguri, L.C.A.G. ; Prezoto, B.C. ; Lebrun, I.
Assuntos: Amino Acid Sequence ; Animals ; Antihypertensive Agents - pharmacology ; Blood pressure ; Blood Pressure - drug effects ; Bothrops ; Bothrops jararaca ; Bradykinin - metabolism ; Chromatography, High Pressure Liquid ; Drug Synergism ; Female ; Hypotension - chemically induced ; Male ; Oligopeptides - blood ; Oligopeptides - isolation & purification ; Oligopeptides - pharmacology ; Peptides ; Peptides - blood ; Peptides - isolation & purification ; Peptides - pharmacology ; Rats ; Rats, Wistar ; Snake ; Trimeresurus flavoviridis ; Vasoactive peptides
É parte de: Comparative biochemistry and physiology. Toxicology & pharmacology, 2009-05, Vol.149 (4), p.552-558
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SourceType-Scholarly Journals-1
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content type line 23
Descrição: Incubation of plasma from the snake Bothrops jararaca ( BJP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for three sequences as: Asn-Pro-Phe-Val-Asp-Ala (fraction 13), Ser-Lys-Pro-Asn-Met-Ser-Asp-Glu-Ser-Leu-Ala-Val-Ala-Ile (fraction 14), Asn-Pro-Phe-Val-Asp-Ala (fraction 15). These peptides display homology with fragments of albumin from Trimeresurus flavoviridis. A bolus intra-arterial injection of the purified or the synthetic peptide produced a strong and sustained vasopressor response in the anaesthetized snake B. jararaca and Wistar rats; this hypotensive effect was also potentiated by captopril, an angiotensin-converting enzyme inhibitor (0.1 mg/kg). The natural concentrations of these peptides in plasma need to be determined and could play a physiological role in snake blood pressure regulation.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca

Barreto, S.A. ; Chaguri, L.C.A.G. ; Prezoto, B.C. ; Lebrun, I.

United States: Elsevier Inc

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