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Lambda-cyhalothrin-induced biochemical and histopathological changes in the liver of rats: Ameliorative effect of ascorbic acid

Fetoui, Hamadi ; Garoui, El Mouldi ; Zeghal, Najiba

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2009-05, Vol.61 (3), p.189-196 [Revista revisada por pares]

Munich: Elsevier GmbH

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Lambda-cyhalothrin-induced biochemical and histopathological changes in the liver of rats: Ameliorative effect of ascorbic acid
Autor: Fetoui, Hamadi ; Garoui, El Mouldi ; Zeghal, Najiba
Materias: Alanine Transaminase - drug effects ; Animals ; Antioxidant enzymes ; Ascorbic Acid - pharmacology ; Aspartate Aminotransferases - drug effects ; Biological and medical sciences ; Catalase - drug effects ; Chemical and Drug Induced Liver Injury ; Glutathione - drug effects ; Insecticides - toxicity ; Investigative techniques, diagnostic techniques (general aspects) ; L-Lactate Dehydrogenase - drug effects ; Lambda-cyhalothrin ; Liver ; Liver Diseases - pathology ; Liver Diseases - prevention & control ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Nitriles - toxicity ; Oxidative damage ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pyrethrins - toxicity ; Rat ; Rats ; Rats, Wistar ; Superoxide Dismutase - drug effects ; Thiobarbituric Acid Reactive Substances - metabolism ; Vitamin C ; Vitamins - pharmacology
Es parte de: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2009-05, Vol.61 (3), p.189-196
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Pyrethroid pesticides were used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegrability. It has widespread applications in agriculture through the world and in Tunisia. The present study investigates lambda-cyhalothrin (LTC) effects on biochemical parameters, hepatotoxicity and their attenuation by vitamin C. Male Wistar rats were randomly divided into three groups of seven each: a control group (C) and two treated groups during 3 weeks with LTC administrated either alone in drinking water for LTC group or coadministred with vitamin C for LTC+vit C group. Lactate deshydrogenase (LDH) activity was significantly increased in liver (+51%, p<0.001) and in plasma (+40%, p<0.001) compared to those of control group. A significant increase of malondialdehyde (MDA) levels in liver (+53%; p<0.001) associated with a decrease in antioxidants enzyme activities and reduced glutathione (GSH) content was observed in LTC group compared to controls. The administration of vitamin C to LTC+vit C group improved all parameters studied. We conclude that LTC induces oxidative stress and modifies biochemical parameters and histological aspects of liver. Administration of vitamin C alleviates the toxicity induced by this synthetic pyrethroid insecticide.
Editor: Munich: Elsevier GmbH
Idioma: Inglés

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Lambda-cyhalothrin-induced biochemical and histopathological changes in the liver of rats: Ameliorative effect of ascorbic acid

Fetoui, Hamadi ; Garoui, El Mouldi ; Zeghal, Najiba

Munich: Elsevier GmbH

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