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Acetaminophen-induced liver damage in mice: Effects of some medicinal plants on the oxidative defense system

Olaleye, M. Tolulope ; Rocha, B.T. João

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2008-03, Vol.59 (5), p.319-327 [Periódico revisado por pares]

Jena: Elsevier GmbH

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Título:
Acetaminophen-induced liver damage in mice: Effects of some medicinal plants on the oxidative defense system
Autor: Olaleye, M. Tolulope ; Rocha, B.T. João
Assuntos: Acetaminophen - toxicity ; Alanine Transaminase - blood ; Alanine Transaminase - drug effects ; Alchornea ; Analgesics, Non-Narcotic - toxicity ; Animals ; Aspartate Aminotransferases - blood ; Aspartate Aminotransferases - drug effects ; Biological and medical sciences ; Calotropis - chemistry ; Calotropis procera ; Catalase - drug effects ; Catalase - metabolism ; Chemical and Drug Induced Liver Injury ; Euphorbiaceae ; Glutathione Peroxidase - drug effects ; Glutathione Peroxidase - metabolism ; Hepatotoxicity ; Hibiscus ; Investigative techniques, diagnostic techniques (general aspects) ; Kigelia africana ; Lipid Peroxidation - drug effects ; Liver Diseases - prevention & control ; Male ; Medical sciences ; Medicinal plants ; Mice ; Oxidative stress ; Oxidative Stress - drug effects ; Paracetamol ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Leaves ; Plants, Medicinal ; Porphobilinogen Synthase - drug effects ; Porphobilinogen Synthase - metabolism ; Superoxide Dismutase - drug effects ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism
É parte de: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2008-03, Vol.59 (5), p.319-327
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Paracetamol (acetaminophen, PCM) is widely used as an over-the-counter analgesic and antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis. Oxidative stress mediated by oxidative capacities of the PCM metabolite ( N-acetyl- p-benzoquinoneimine (NAPQI), is considered as the main cause of hepatotoxicity of PCM. This work therefore seeks to induce liver damage in mice using single dose (250 mg/kg) of acetaminophen and to evaluate the possible protective effects of administration (100 mg/kg) of some medicinal plants ( Kigelia africana, Calotropis procera, Hibiscus sabdariffa and Alchornea cordifolia) on PCM-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. Equally, comparative effects of these plants on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), gluthathione peroxidase (GPx), and δ-aminolevulinate dehydratase ( δ-ALA-D) activities, were also evaluated in the mouse liver homogenate. Paracetamol caused liver damage as evident by statistically significant ( P<0.05) increased in plasma activities of AST and ALT. There were general statistically significant losses in the activities of SOD, GPx, CAT, and δ-ALA-D and an increase in TBARS in the liver of paracetamol-treated group compared with the control group. However, all the tested plants except Calotropis procera were able to counteract these effects. The present results suggest that these plants can act as hepatoprotectives against paracetamol toxicity and that the mechanism by which they do this is by acting as antioxidants.
Editor: Jena: Elsevier GmbH
Idioma: Inglês

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Acetaminophen-induced liver damage in mice: Effects of some medicinal plants on the oxidative defense system

Olaleye, M. Tolulope ; Rocha, B.T. João

Jena: Elsevier GmbH

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