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Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation

Moore, Melissa J. ; Proudfoot, Nick J.

Cell, 2009-02, Vol.136 (4), p.688-700 [Periódico revisado por pares]

Elsevier Inc

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  • Título:
    Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation
  • Autor: Moore, Melissa J. ; Proudfoot, Nick J.
  • É parte de: Cell, 2009-02, Vol.136 (4), p.688-700
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5′ cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.
  • Editor: Elsevier Inc
  • Idioma: Inglês

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