Idioma:

Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs

Zhang, Hai-na ; Xu, Qiao-qiao ; Thakur, Abhimanyu ; Alfred, Martin Omondi ; Chakraborty, Manas ; Ghosh, Arunima ; Yu, Xu-ben

Life sciences (1973), 2018-11, Vol.213, p.258-268 [Periódico revisado por pares]

Netherlands: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs
Autor: Zhang, Hai-na ; Xu, Qiao-qiao ; Thakur, Abhimanyu ; Alfred, Martin Omondi ; Chakraborty, Manas ; Ghosh, Arunima ; Yu, Xu-ben
Assuntos: Angiogenesis ; Angiogenesis Inducing Agents ; Animals ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - physiopathology ; Blood flow ; Cardiovascular diseases ; Cardiovascular Diseases - physiopathology ; Complications ; Diabetes mellitus ; Diabetes Mellitus - genetics ; Diabetes Mellitus - physiopathology ; Endothelial cells ; Endothelial Cells - physiology ; Endothelium ; Endothelium, Vascular - physiopathology ; Filtration ; Heart diseases ; Humans ; Hyperglycaemia ; Hyperglycemia ; Hyperglycemia - genetics ; Hyperglycemia - physiopathology ; Hypertension ; Hypertension - genetics ; Hypertension - physiopathology ; Inflammation ; Inflammation - physiopathology ; MicroRNAs - genetics ; MicroRNAs - physiology ; miRNA ; Muscles ; Neurological diseases ; Nitric Oxide ; Nitric Oxide Synthase Type III ; Nitric-oxide synthase ; Non-coding RNA ; Obesity ; Regulatory mechanisms (biology) ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - physiology ; Smooth muscle
É parte de: Life sciences (1973), 2018-11, Vol.213, p.258-268
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The vascular endothelium acts as a barrier between the blood flow and the inner lining of the vessel wall, and it functions as a filtering machinery to filter out any unwanted transfer of materials from both sides (i.e. the blood and the surrounding tissues). It is evident that diseases such as diabetes, obesity, and hypertension disturb the normal endothelial functions in humans and lead to endothelial dysfunction, which may further precede to the development of atherosclerosis. Long non-coding RNAs and micro RNAs both are types of non-coding RNAs which, in the recent years, have increasingly been studied in the pathophysiology of many diseases including diabetes, obesity, cardiovascular diseases, neurological diseases, and others. Recent findings have pointed out important aspects on their relevance to endothelial function as well as dysfunction of the system which may arise from presence of diseases such as diabetes and hypertension. Diabetes or hypertension-mediated endothelial dysfunction show characteristics such as reduced nitric oxide synthesis through suppression of endothelial nitric oxide synthase activity in endothelial cells, reduced sensitivity of nitric oxide in smooth muscle cells, and inflammation – all of which have been either shown to be directly caused by gene regulatory mechanisms of non-coding RNAs or shown to be having a correlation with them. In this review, we aim to discuss such findings on the role of these non-coding RNAs in diabetes or hypertension-associated endothelial dysfunction and the related mechanisms that may pave the way for alleviating endothelial dysfunction and its related complications such as atherosclerosis. [Display omitted]
Editor: Netherlands: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs

Zhang, Hai-na ; Xu, Qiao-qiao ; Thakur, Abhimanyu ; Alfred, Martin Omondi ; Chakraborty, Manas ; Ghosh, Arunima ; Yu, Xu-ben

Netherlands: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.