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Postprandial augmentation index is reduced in adults with prediabetes following continuous and interval exercise training

Eichner, Natalie Z. M. ; Gaitán, Julian M. ; Gilbertson, Nicole M. ; Khurshid, Mahnoor ; Weltman, Arthur ; Malin, Steven K.

Experimental physiology, 2019-02, Vol.104 (2), p.264-271 [Periódico revisado por pares]

England: John Wiley & Sons, Inc

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  • Título:
    Postprandial augmentation index is reduced in adults with prediabetes following continuous and interval exercise training
  • Autor: Eichner, Natalie Z. M. ; Gaitán, Julian M. ; Gilbertson, Nicole M. ; Khurshid, Mahnoor ; Weltman, Arthur ; Malin, Steven K.
  • Assuntos: Body Mass Index ; Cardiorespiratory fitness ; cardiovascular disease ; Cardiovascular diseases ; Diabetes ; Exercise ; Exercise - physiology ; Fasting ; Female ; Femur ; fitness ; Fitness training programs ; Glucose ; Glucose - metabolism ; Glucose tolerance ; Glucose Tolerance Test - methods ; Heart rate ; Heart Rate - physiology ; Humans ; hypertension ; Insulin ; Insulin Resistance - physiology ; insulin sensitivity ; Laboratory testing ; Middle Aged ; obesity ; Physical training ; Postprandial Period - physiology ; Prediabetic State - physiopathology ; Pulse Wave Analysis - methods ; type 2 diabetes ; Vascular Stiffness - physiology
  • É parte de: Experimental physiology, 2019-02, Vol.104 (2), p.264-271
  • Notas: Funding information
    Edited by: James Jones
    Funding was provided by the University of Virginia Curry School of Education and Launchpad Award to S.K.M. S.K.M. is supported by National Institutes of Health RO1‐HL130296.
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  • Descrição: New Findings What is the central question of this study? We compared high‐intensity interval versus continuous training on fasting and postprandial arterial stiffness in people with prediabetes. What is the main finding and its importance? We show, for the first time, that exercise improves the augmentation index during the postprandial state, but not the fasted state, in adults with prediabetes. However, the fasted augmentation index improved in relationship to exercise dose, as assessed by kilocalories per session. Collectively, these findings suggest that short‐term exercise can improve arterial compliance in adults with prediabetes. Therefore, lifestyle interventions designed to reduce arterial stiffness could have considerable clinical impact. People with prediabetes have elevated risk for cardiovascular disease, in part, owing to arterial stiffness mediated by low insulin sensitivity. However, the effect the intensity and/or amount (i.e. kilocalories per session) of short‐term exercise training on fasting and postprandial arterial stiffness is unknown. We tested the hypothesis that increased intensity and dose (i.e. amount) of exercise would be correlated with reduced fasting and postprandial arterial stiffness in obese adults with prediabetes. After randomization, 31 adults (age 61.4 ± 8.3 years, body mass index 32.1 ± 5.4 kg m−2) with prediabetes performed supervised continuous (CONT; n = 17; 70% of peak heart rate) or interval (INT; n = 14; 3 min at 50% of peak heart rate and 3 min at 90% of peak heart rate) cycling training for 60 min day−1 over 2 weeks. The amount of exercise was calculated using regression equations derived from oxygen uptake (V̇O2) and heart rate. Arterial stiffness [augmentation index (AI) and cartoid–femoral pulse wave velocity], insulin and glucose were determined during a 180 min 75 g oral glucose tolerance test (OGTT) and analysed by the total area under the curve (tAUC) pre‐ versus post‐training. The simple index of insulin sensitivity, (SIIS)OGTT, was calculated; aerobic fitness (peak V̇O2) and body mass were also assessed. Short‐term training had no effect on weight but did improve peak V̇O2 (P = 0.003), glucose tAUC180min (P = 0.01) and insulin sensitivity (P = 0.002), independent of intensity. The CONT and INT exercise significantly reduced AI 2 h postprandial (P = 0.008) and tAUC180min (P = 0.03). Reductions in fasted AI were related to exercise dose (trend: r = −0.37, P = 0.055). Increased peak V̇O2 was linked to reduced fasted (r = −0.47, P = 0.01) and tAUC180min AI (r = −0.39, P = 0.05). Decreased AI tAUC180min was correlated with increased insulin sensitivity (r = −0.50, P = 0.009). Short‐term CONT and INT training reduced postprandial arterial stiffness comparably in adults with prediabetes.
  • Editor: England: John Wiley & Sons, Inc
  • Idioma: Inglês
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