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T cells and the skin: from protective immunity to inflammatory skin disorders

Ho, Allen W ; Kupper, Thomas S

Nature reviews. Immunology, 2019-08, Vol.19 (8), p.490-502 [Periódico revisado por pares]

England: Nature Publishing Group

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  • Título:
    T cells and the skin: from protective immunity to inflammatory skin disorders
  • Autor: Ho, Allen W ; Kupper, Thomas S
  • Assuntos: Animals ; Effector cells ; Humans ; Immunity ; Immunologic Memory ; Immunological memory ; Inflammation - immunology ; Inflammatory diseases ; Lymphocytes ; Lymphocytes T ; Memory cells ; Microorganisms ; Skin - immunology ; Skin diseases ; Skin Diseases - immunology ; T-Lymphocytes - immunology
  • É parte de: Nature reviews. Immunology, 2019-08, Vol.19 (8), p.490-502
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-2
  • Descrição: Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the generation of antigen-specific effector T cells, which home to cutaneous sites of injury or infection. Long-lasting immunity against future immune challenges is mediated by memory T cells. Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (T ) cells, which remain in skin for long periods of time and mediate durable protective immunity. These T cells also appear to drive many inflammatory diseases of skin. Here, we consider how a better understanding of cutaneous T cell responses can aid in the development of effective new therapies for immune-mediated cutaneous diseases.
  • Editor: England: Nature Publishing Group
  • Idioma: Inglês
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