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Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Mantovani, Alberto ; Dinarello, Charles A. ; Molgora, Martina ; Garlanda, Cecilia

Immunity (Cambridge, Mass.), 2019-04, Vol.50 (4), p.778-795 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
Autor: Mantovani, Alberto ; Dinarello, Charles A. ; Molgora, Martina ; Garlanda, Cecilia
Assuntos: Adaptive immunity ; Adaptive Immunity - immunology ; Animals ; Autoimmune diseases ; Autoimmunity ; Cancer ; Cardiovascular Diseases - immunology ; Cloning ; Cytokines ; Cytokines - genetics ; Cytokines - immunology ; Cytokines - physiology ; Gastrointestinal Diseases - immunology ; Hematopoiesis - immunology ; Homeostasis ; Humans ; Immune response ; Immunity ; Immunity, Innate - immunology ; Inflammation ; Inflammation - immunology ; Interleukin 1 ; Interleukin 18 ; Interleukin-1 - immunology ; Interleukin-1 - physiology ; Kinases ; Ligands ; Lymphocytes - immunology ; Mice ; Mice, Knockout ; Multigene Family ; Neoplasms - immunology ; Neurodegenerative Diseases - immunology ; Proteins ; Receptors, Cytokine - genetics ; Receptors, Cytokine - immunology ; Regulation
É parte de: Immunity (Cambridge, Mass.), 2019-04, Vol.50 (4), p.778-795
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family—IL-18, IL-33, IL-36, IL-37, and IL-38—in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine. Mantovani et al. review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and discuss how our growing understanding of the context-dependent roles of these cytokines are informing advances in the clinic.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Mantovani, Alberto ; Dinarello, Charles A. ; Molgora, Martina ; Garlanda, Cecilia

United States: Elsevier Inc

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