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Efficacy of ω-3 supplementation on nutritional status, skeletal muscle, and chemoradiotherapy toxicity in cervical cancer patients: A randomized, triple-blind, clinical trial conducted in a middle-income country

Aredes, Mariah Azevedo ; da Camara, Alex Oliveira ; de Paula, Nathália Silva ; Fraga, Karla Yasmin Dias ; do Carmo, Maria das Graças Tavares ; Chaves, Gabriela Villaça

Nutrition (Burbank, Los Angeles County, Calif.), 2019-11, Vol.67-68, p.110528-110528, Article 110528 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Efficacy of ω-3 supplementation on nutritional status, skeletal muscle, and chemoradiotherapy toxicity in cervical cancer patients: A randomized, triple-blind, clinical trial conducted in a middle-income country
  • Autor: Aredes, Mariah Azevedo ; da Camara, Alex Oliveira ; de Paula, Nathália Silva ; Fraga, Karla Yasmin Dias ; do Carmo, Maria das Graças Tavares ; Chaves, Gabriela Villaça
  • Assuntos: Anthropometry ; Body composition ; Body weight ; Cancer ; Cervical cancer ; Cervix ; Chemoradiotherapy ; Chemotherapy ; Clinical trials ; Computed tomography ; Dietary supplements ; Infiltration ; Muscles ; Musculoskeletal system ; Nutritional status ; Oils & fats ; Olive oil ; Patients ; Population studies ; Preservation ; Quality ; Radiation therapy ; Randomization ; Skeletal muscle ; Toxicity ; ω-3
  • É parte de: Nutrition (Burbank, Los Angeles County, Calif.), 2019-11, Vol.67-68, p.110528-110528, Article 110528
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-News-1
    ObjectType-Feature-3
    content type line 23
  • Descrição: •This was the first randomized controlled trial focusing on ω-3 supplementation in cervical cancer.•We used an innovative methodology for skeletal muscle quality assessment.•The results suggested a protective role of ω-3 in skeletal muscle quality.•Supplementation with ω-3 significantly reduced chemoradiotherapy toxicity. Supplementation with ω-3 has been shown to favor the preservation of body weight and skeletal muscle. The aim of this study was to evaluate the efficacy of ω-3 supplementation on nutritional status, skeletal muscle quantity and quality, and toxicity for treatment of women with cervical cancer. This was a randomized, triple-blinded, placebo-controlled clinical trial in women diagnosed with cervical cancer who underwent chemoradiotherapy between March 2016 and August 2017. The intervention group received four capsules with ω-3 (2.5 g/d) and the control group (CG) received the same number of identical-looking capsules with olive oil, for 45 d. Nutritional status was measured by anthropometry and Patient-Generated Subjective Global Assessment. Body composition was assessed by computed tomography. The skeletal muscle index was calculated using the range –29 to +150 HU. For skeletal muscle quality, the area comprised between –29 and +29 HU was denominated low-radiodensity skeletal muscle index and the range between +30 and +150 HU high-radiodensity skeletal muscle index, representing the skeletal muscle area with high or low intramuscular fat infiltration, respectively. The study population comprised 40 patients, with an average age 44.53 ± 8.73. The intervention group maintained body weight and showed an improvement in Patient-Generated Subjective Global Assessment score. A significant reduction in skeletal muscle index was observed in both groups. However, in regard to skeletal muscle quality, patients in the intervention group preserved low- and high-radiodensity skeletal muscle index, whereas those in the control group had increased low-radiodensity skeletal muscle index and significantly reduced high-radiodensity skeletal muscle index, reflecting high intramuscular fat infiltration only in the control group. The incidence of chemotherapy toxicity was significantly lower in the intervention group. The results suggest that ω-3 supplementation is effective in maintaining nutritional status, skeletal muscle quality, and reduced symptoms of chemoradiotherapy among women with cervical cancer.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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