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Iron homeostasis and oxidative stress: An intimate relationship

Galaris, Dimitrios ; Barbouti, Alexandra ; Pantopoulos, Kostas

Biochimica et biophysica acta. Molecular cell research, 2019-12, Vol.1866 (12), p.118535-118535, Article 118535 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Iron homeostasis and oxidative stress: An intimate relationship
  • Autor: Galaris, Dimitrios ; Barbouti, Alexandra ; Pantopoulos, Kostas
  • Assuntos: Animals ; Ferroptosis ; Homeostasis ; Humans ; Iron - metabolism ; Lipid peroxidation ; Oxidative Stress ; Oxygen ; Reactive Oxygen Species - metabolism ; Redox signaling ; Signal Transduction
  • É parte de: Biochimica et biophysica acta. Molecular cell research, 2019-12, Vol.1866 (12), p.118535-118535, Article 118535
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Iron is a transition metal and essential constituent of almost all living cells and organisms. As component of various metalloproteins it is involved in critical biochemical processes such as transport of oxygen in tissues, electron transfer reactions during respiration in mitochondria, synthesis and repair of DNA, metabolism of xenobiotics, etc. However, when present in excess within cells and tissues, iron disrupts redox homeostasis and catalyzes the propagation of reactive oxygen species (ROS), leading to oxidative stress. ROS are critical for physiological signaling pathways, but oxidative stress is associated with tissue injury and disease. At the cellular level, oxidative stress may lead to ferroptosis, an iron-dependent form of cell death. In this review, we focus on the intimate relationship between iron metabolism and oxidative stress in health and disease. We discuss aspects of redox- and iron-mediated signaling, toxicity, ferroptotic cell death, homeostatic pathways and pathophysiological implications. •Iron is an essential nutrient but also a potential biohazard.•Iron catalyzes formation of reactive radicals via Fenton chemistry.•Iron overload predisposes to oxidative stress and tissue injury.•Only unshielded labile iron exhibits redox reactivity in vivo.•Labile iron is critical for ferroptosis and can be neutralized by chelating drugs.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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