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Utility of Blood Cultures and Empiric Antibiotics in Febrile Pediatric Hemophilia Patients With Central Venous Access Devices

Al-Samkari, Hanny ; Ozonoff, Al ; Landschaft, Assaf ; Kimia, Rotem ; Harper, Marvin B ; Croteau, Stacy E ; Kimia, Amir A

Pediatric emergency care, 2021-12, Vol.37 (12), p.e1531-e1534 [Periódico revisado por pares]

United States: Copyright Wolters Kluwer Health, Inc. All rights reserved

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  • Título:
    Utility of Blood Cultures and Empiric Antibiotics in Febrile Pediatric Hemophilia Patients With Central Venous Access Devices
  • Autor: Al-Samkari, Hanny ; Ozonoff, Al ; Landschaft, Assaf ; Kimia, Rotem ; Harper, Marvin B ; Croteau, Stacy E ; Kimia, Amir A
  • Assuntos: Anti-Bacterial Agents - therapeutic use ; Bacteremia - drug therapy ; Bacteremia - epidemiology ; Blood Culture ; Child ; Cross-Sectional Studies ; Hemophilia A - complications ; Hemophilia A - drug therapy ; Humans ; Retrospective Studies
  • É parte de: Pediatric emergency care, 2021-12, Vol.37 (12), p.e1531-e1534
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: BACKGROUNDChildren with hemophilia frequently require long-term central venous access devices (CVADs) for regular infusion of factor products. Hemophilia patients are not immunocompromised, but the presence and use of CVADs are associated with infections including bacteremia. Currently, the utility of blood cultures in evaluation of the febrile hemophilia patient with an indwelling CVAD is unknown, nor is optimal empiric antibiotic use. METHODSWe performed a retrospective cross-sectional study of febrile immunocompetent hemophilia patients with CVADs presenting to a large academic urban pediatric emergency department from 1995 to 2017. We used a natural language processing electronic search, followed by manual chart review to construct the cohort. We analyzed rate of pathogen recovery from cultures of blood in subgroups of hemophilia patients, the pathogen profile, and the reported pathogen susceptibilities to ceftriaxone. RESULTSNatural language processing electronic search identified 181 visits for fever among hemophilia patients with indwelling CVADs of which 147 cases from 44 unique patients met study criteria. Cultures of blood were positive in 56 (38%) of 147 patients (95% confidence interval, 30%–47%). Seventeen different organisms were isolated (10 pathogens and 7 possible pathogens) with Staphylococcus aureus and coagulase-negative Staphylococcus species as the most common. Thirty-four percent of isolates were reported as susceptible to ceftriaxone. Positive blood cultures were more common in cases involving patients with inhibitors (n = 71) versus those without (n = 76), odds ratio, 7.4 (95% confidence interval, 3.5–15.9). This was observed irrespective of hemophilia type. CONCLUSIONSFebrile immunocompetent hemophilia patients with indwelling CVADs have high rates of bacteremia. Empiric antimicrobial therapy should be targeted to anticipated pathogens and take into consideration local susceptibility patterns for Staphylococcus aureus.
  • Editor: United States: Copyright Wolters Kluwer Health, Inc. All rights reserved
  • Idioma: Inglês
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