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Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Xiao, Kangpeng ; Zhai, Junqiong ; Feng, Yaoyu ; Zhou, Niu ; Zhang, Xu ; Zou, Jie-Jian ; Li, Na ; Guo, Yaqiong ; Li, Xiaobing ; Shen, Xuejuan ; Zhang, Zhipeng ; Shu, Fanfan ; Huang, Wanyi ; Li, Yu ; Zhang, Ziding ; Chen, Rui-Ai ; Wu, Ya-Jiang ; Peng, Shi-Ming ; Huang, Mian ; Xie, Wei-Jun ; Cai, Qin-Hui ; Hou, Fang-Hui ; Chen, Wu ; Xiao, Lihua ; Shen, Yongyi

Nature (London), 2020-07, Vol.583 (7815), p.286-289 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins
Autor: Xiao, Kangpeng ; Zhai, Junqiong ; Feng, Yaoyu ; Zhou, Niu ; Zhang, Xu ; Zou, Jie-Jian ; Li, Na ; Guo, Yaqiong ; Li, Xiaobing ; Shen, Xuejuan ; Zhang, Zhipeng ; Shu, Fanfan ; Huang, Wanyi ; Li, Yu ; Zhang, Ziding ; Chen, Rui-Ai ; Wu, Ya-Jiang ; Peng, Shi-Ming ; Huang, Mian ; Xie, Wei-Jun ; Cai, Qin-Hui ; Hou, Fang-Hui ; Chen, Wu ; Xiao, Lihua ; Shen, Yongyi
Assuntos: Amino acids ; Animals ; Antibodies ; Bats ; Betacoronavirus - classification ; Betacoronavirus - genetics ; Betacoronavirus - isolation & purification ; China ; Chiroptera - virology ; Chlorocebus aethiops ; Coronaviridae ; Coronavirus Envelope Proteins ; Coronavirus Infections - epidemiology ; Coronavirus Infections - pathology ; Coronavirus Infections - transmission ; Coronavirus Infections - veterinary ; Coronavirus Infections - virology ; Coronavirus M Proteins ; Coronavirus Nucleocapsid Proteins ; Coronaviruses ; COVID-19 ; Disease Reservoirs - virology ; Disease transmission ; Enzymes ; Eutheria - virology ; Evolution, Molecular ; Genes ; Genome, Viral - genetics ; Genomes ; Genomic analysis ; Genomics ; Health risks ; Host Specificity ; Humans ; Lung - pathology ; Lung - virology ; Malaysia ; Mammals ; Middle East respiratory syndrome ; Nucleocapsid Proteins - genetics ; Outbreaks ; Pandemics ; Phosphoproteins ; Phylogenetics ; Phylogeny ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - transmission ; Pneumonia, Viral - virology ; Polymerase Chain Reaction ; Proteins ; Public health ; Recombination ; Recombination, Genetic ; Respiratory diseases ; SARS-CoV-2 ; Sequence Alignment ; Sequence Analysis, RNA ; Sequence Homology, Nucleic Acid ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Spike Glycoprotein, Coronavirus - genetics ; Vero Cells ; Viral diseases ; Viral Envelope Proteins - genetics ; Viral Matrix Proteins - genetics ; Viruses ; Wildlife ; Wildlife trade ; Zoonoses - transmission ; Zoonoses - virology
É parte de: Nature (London), 2020-07, Vol.583 (7815), p.286-289
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SourceType-Scholarly Journals-1
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Descrição: The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health . The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG13 . Although bats may be the reservoir host for a variety of coronaviruses , it remains unknown whether SARS-CoV-2 has additional host species. Here we show that a coronavirus, which we name pangolin-CoV, isolated from a Malayan pangolin has 100%, 98.6%, 97.8% and 90.7% amino acid identity with SARS-CoV-2 in the E, M, N and S proteins, respectively. In particular, the receptor-binding domain of the S protein of pangolin-CoV is almost identical to that of SARS-CoV-2, with one difference in a noncritical amino acid. Our comparative genomic analysis suggests that SARS-CoV-2 may have originated in the recombination of a virus similar to pangolin-CoV with one similar to RaTG13. Pangolin-CoV was detected in 17 out of the 25 Malayan pangolins that we analysed. Infected pangolins showed clinical signs and histological changes, and circulating antibodies against pangolin-CoV reacted with the S protein of SARS-CoV-2. The isolation of a coronavirus from pangolins that is closely related to SARS-CoV-2 suggests that these animals have the potential to act as an intermediate host of SARS-CoV-2. This newly identified coronavirus from pangolins-the most-trafficked mammal in the illegal wildlife trade-could represent a future threat to public health if wildlife trade is not effectively controlled.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

England: Nature Publishing Group

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