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Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma

Meyers, Paul A.

Advances in experimental medicine and biology, 2020, Vol.1257, p.133-139 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma
Autor: Meyers, Paul A.
Assuntos: Acetylmuramyl-Alanyl-Isoglutamine ; Adjuvant therapy ; Animals ; Bone Neoplasms - drug therapy ; Clinical Trials as Topic ; Dogs ; Humans ; Immunologic Factors - administration & dosage ; Immunotherapy ; Liposomes - administration & dosage ; Liposomes - chemistry ; Macrophages ; Muramyl tripeptide ; Osteosarcoma ; Osteosarcoma - drug therapy ; Phosphatidylethanolamines - administration & dosage
É parte de: Advances in experimental medicine and biology, 2020, Vol.1257, p.133-139
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: The recruitment of autologous macrophages to attack osteosarcoma represents a novel immunotherapy approach to the treatment of osteosarcoma. Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) was derived as a compound with the ability to stimulate macrophages to destroy autologous osteosarcoma tumor cells. Preclinical studies including studies in dogs with spontaneously arising osteosarcoma showed the ability of L-MTP-PE to control microscopic metastatic disease in osteosarcoma. A pivotal clinical trial led to the approval of L-MTP-PE for the treatment of newly diagnosed osteosarcoma in over 40 countries.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma

Meyers, Paul A.

Cham: Springer International Publishing

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