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Role of vacuum assisted excision in minimising overtreatment of ductal atypias

McMahon, MA ; Haigh, I ; Chen, Y ; Millican-Slater, RA ; Sharma, N

European journal of radiology, 2020-10, Vol.131, p.109258-109258, Article 109258 [Periódico revisado por pares]

Ireland: Elsevier B.V

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Título:
Role of vacuum assisted excision in minimising overtreatment of ductal atypias
Autor: McMahon, MA ; Haigh, I ; Chen, Y ; Millican-Slater, RA ; Sharma, N
Assuntos: AIDEP ; Biopsy, Needle - methods ; Breast - diagnostic imaging ; Breast - pathology ; Breast - surgery ; Breast cancer ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Carcinoma in Situ - diagnostic imaging ; Carcinoma in Situ - pathology ; Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Carcinoma, Intraductal, Noninfiltrating - surgery ; Ductal atypia ; FEA ; Female ; Humans ; Hyperplasia - diagnostic imaging ; Hyperplasia - pathology ; Hyperplasia - surgery ; Mammography ; Medical Overuse - prevention & control ; Precancerous Conditions - diagnostic imaging ; Precancerous Conditions - pathology ; Precancerous Conditions - surgery ; Retrospective Studies ; Surveillance mammography ; Vacuum ; Vacuum assisted-biopsy ; Vacuumassisted-excision
É parte de: European journal of radiology, 2020-10, Vol.131, p.109258-109258, Article 109258
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SourceType-Scholarly Journals-1
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Descrição: B3 lesions are indeterminate lesions of uncertain malignant potential. They include lesions with and without epithelial atypia. Those with atypia include atypical intraductal epithelial proliferation (AIDEP)/atypical ductal hyperplasia (ADH) and flat epithelial atypia (FEA). They are traditionally managed with surgery. Vacuum assisted excision (VAE) allows larger samples to be obtained using a vacuum assisted biopsy (VAB) device, which equates to a surgical biopsy. We propose that VAE and mammographic surveillance is a safe alternative to surgery in managing the ductal atypias; (AIDEP/ADH and FEA). Retrospective analysis of prospectively collected data on B3 lesions (April 2009 - March 2016) from consecutive breast screening patients diagnosed with AIDEP/ADH or FEA on initial diagnostic core biopsy. Mammographic abnormality, breast density, size, management pathway and upgrade to cancer and types of cancer were also collected during the treatment pathway and 5 year surveillance period (April 2009 - April 2019). 273 cases of ductal atypia were identified. 187/273 (68.5 %) cases were managed with VAE only as no upgrade to malignancy and then 5 year mammographic surveillance. 34/273 (12.5 %) cases had a VAE diagnosing malignancy. 24/273 (8.8 %) cases had a VAE and then a surgical biopsy due to radiological or pathological concern, 8/24 upgraded to malignancy. 22/273 (8%) cases had a surgical diagnostic biopsy, 9/22 (41 %) cases were upgraded to malignancy. In total 51/273 (19 %) cases were diagnosed with cancer on the new pathway (13 invasive (all ER positive and Her2 negative) and 38 non-invasive, (34 ductal carcinoma in situ (DCIS) and 4 cases of lobular carcinoma in situ (LCIS)). While 17/273 (6.2 %) cases developed malignancy (12 invasive (all HER2 negative) and 4 DCIS and 1 LCIS) during the 5 year surveillance period. VAE is a safe alternative to surgery in managing ductal atypias. 187/273 (68.5 %) women avoided surgery. While 34/51 cancers (66.7 %) were diagnosed preoperatively using VAE, allowing the women to have a single therapeutic procedure.
Editor: Ireland: Elsevier B.V
Idioma: Inglês

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Role of vacuum assisted excision in minimising overtreatment of ductal atypias

McMahon, MA ; Haigh, I ; Chen, Y ; Millican-Slater, RA ; Sharma, N

Ireland: Elsevier B.V

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