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Long-term voluntary running modifies the levels of proteins of the excitatory/inhibitory system and reduces reactive astrogliosis in the brain of Ts65Dn mouse model for Down syndrome

Kida, Elizabeth ; Walus, Marius ; Albertini, Giorgio ; Golabek, Adam A.

Brain research, 2021-09, Vol.1766, p.147535-147535, Article 147535 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Long-term voluntary running modifies the levels of proteins of the excitatory/inhibitory system and reduces reactive astrogliosis in the brain of Ts65Dn mouse model for Down syndrome
Autor: Kida, Elizabeth ; Walus, Marius ; Albertini, Giorgio ; Golabek, Adam A.
Assuntos: Animals ; Brain - metabolism ; Brain - pathology ; Disease Models, Animal ; Down syndrome ; Down Syndrome - genetics ; Down Syndrome - metabolism ; Down Syndrome - pathology ; Excitation/inhibition ; Excitatory Amino Acid Transporter 2 - metabolism ; Female ; GFAP ; Gliosis - metabolism ; Gliosis - pathology ; Gliosis - therapy ; Glutamate Decarboxylase - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Physical Conditioning, Animal - physiology ; Physical Conditioning, Animal - trends ; Proteins ; Receptors, GABA - metabolism ; Receptors, Metabotropic Glutamate - metabolism ; Time Factors ; Ts65Dn mice ; Wheel running
É parte de: Brain research, 2021-09, Vol.1766, p.147535-147535, Article 147535
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: •Ts65Dn mice, a model of DS, show excitation/inhibition system imbalance and gliosis.•Running improved learning, memory, and locomotor deficits of Ts65Dn mice.•Running changed the levels of some proteins of the excitation/inhibition system.•Running reduced reactive astrogliosis.•The effect of running depended on the age at onset of running. We showed previously that voluntary long-term running improved cognition and motor skills, but in an age-dependent manner, in the Ts65Dn mouse model for Down syndrome (DS). Presently, we investigated the effect of running on the levels of some key proteins of the excitatory/inhibitory system, which is impaired in the trisomic brain, and on astroglia, a vital component of this system. Ts65Dn mice had free access to a running wheel for 9–13 months either from weaning or from the age of 7 months. Sedentary Ts65Dn mice served as controls. We found that running modified the levels of four of the seven proteins we tested that are associated with the glutamatergic/GABA–ergic system. Thus, Ts65Dn runners demonstrated increased levels of glutamine synthetase and metabotropic glutamate receptor 1 and decreased levels of glutamate transporter 1 and glutamic acid decarboxylase 65 (GAD65) versus sedentary mice, but of metabotropic glutamate receptor 1 and GAD65 only in the post-weaning cohort. GAD67, ionotropic N-methyl-D-aspartate type receptor subunit 1, and GABAAα5 receptors’ levels were similar in runners and sedentary animals. The number of glial fibrillary acidic protein (GFAP)–positive astrocytes and the levels of GFAP were significantly reduced in runners relative to sedentary mice. Our study provides new insight into the mechanisms underlying the beneficial effect of voluntary, sustained running on function of the trisomic brain by identifying the involvement of proteins associated with glutamatergic and GABAergic systems and reduction in reactive astrogliosis.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Long-term voluntary running modifies the levels of proteins of the excitatory/inhibitory system and reduces reactive astrogliosis in the brain of Ts65Dn mouse model for Down syndrome

Kida, Elizabeth ; Walus, Marius ; Albertini, Giorgio ; Golabek, Adam A.

Netherlands: Elsevier B.V

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