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Marching band model for simulating a single muscle fiber action potential

Nandedkar, Sanjeev D. ; Stålberg, Erik V.

Clinical neurophysiology, 2022-02, Vol.134, p.37-42 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Marching band model for simulating a single muscle fiber action potential
  • Autor: Nandedkar, Sanjeev D. ; Stålberg, Erik V.
  • Assuntos: Action potential ; Action Potentials - physiology ; Computer Simulation ; End-plate ; Humans ; Models, Neurological ; Muscle fiber ; Muscle Fibers, Skeletal - physiology ; Positive sharp wave ; SFEMG ; Simulation
  • É parte de: Clinical neurophysiology, 2022-02, Vol.134, p.37-42
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •A modification to previously described line source model for calculating a single muscle fiber action potential is described.•Change in action potential waveform at different sites from end-plate to tendon is demonstrated and discussed.•The conceptually simple model simulated waveforms seen in clinical recordings, and using complex volume conductor models. We describe a mathematical model to calculate a single muscle fiber action potential (AP). Based on a marching band pattern, it is an enhancement to our previously described “modified line source” model. Calculations were performed using an Excel spread sheet. AP was simulated for a 200 mm long muscle fiber with 60 µm diameter, propagation velocity of 4 m/s, and end-plate located at the center. Several different electrode locations were used to calculate the AP. The AP amplitude was highest at the end-plate where the waveform was biphasic with initial negativity. When the electrode was moved towards the tendon, the amplitude decreased for the first 1.5 mm. The AP was triphasic and its waveform was relatively constant at electrode positions beyond 1.5 mm from the end-plate. It matched the calculations using the modified line source model. When the electrode was near the tendon, the AP amplitude decreased asymmetrically and waveform became biphasic resembling a positive sharp wave. The model is conceptually and computationally simple. It simulated the expected AP shape at different electrode positions along the muscle fiber. The waveforms are similar to those obtained from mathematically complex volume conductor models. The revised model can be useful for teaching and future simulation studies.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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