Idioma:

Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets

Abad, Miriam ; Mendoza, Gracia ; Usón, Laura ; Arruebo, Manuel ; Piñol, Milagros ; Sebastián, Víctor ; Oriol, Luis

Macromolecular bioscience, 2022-05, Vol.22 (5), p.e2100528-n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets
Autor: Abad, Miriam ; Mendoza, Gracia ; Usón, Laura ; Arruebo, Manuel ; Piñol, Milagros ; Sebastián, Víctor ; Oriol, Luis
Assuntos: Biocompatibility ; block copolymer micelles ; Block copolymers ; Cell lines ; Cell membranes ; Cell viability ; Chemical synthesis ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; drug delivery ; Drug Delivery Systems ; Electron microscopy ; Hybrid systems ; Hydrophobicity ; I.R. radiation ; Irradiation ; Magnetic amplifiers ; Micelles ; Microfluidics ; Nanoparticles ; Nanosheets ; Naproxen ; Pd nanosheets ; photothermal therapy ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Polymers ; Polymers - chemistry ; Polymers - pharmacology ; Polymethacrylates ; Prepolymers ; Spectroscopy
É parte de: Macromolecular bioscience, 2022-05, Vol.22 (5), p.e2100528-n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The synthesis of polymeric nanoparticles from a block copolymer based on poly(ethylene glycol) and a polymethacrylate containing the nucleobase analog 2,6‐diacylaminopyridine is optimized by microfluidics to obtain homogeneous spherical micelles. Loading and delivery properties are studied using naproxen as a model. The incorporation of a Pd precursor in the polymer organic solution fed into the micromixer allows the preparation of Pd(II) precursor‐polymer hybrid systems and the subsequent reduction with CO leads to the in situ synthesis of Pd nanosheets inside of the hydrophobic core of the polymeric micelles. This methodology is highly efficient to yield all polymeric nanoparticles loaded with Pd nanosheets as detected by electron microscopy and energy‐dispersive X‐ray spectroscopy. The cell viability of these Pd nanosheets‐containing polymeric nanoparticles is evaluated using five cell lines, showing a high cytocompatibility at the tested concentrations without detrimental effects in cell membrane and nuclei. Furthermore, the use of these hybrid polymeric nanoparticles as photothermal transductors is evaluated using near infrared as irradiation source as well as its application in photothermal therapy using different cell lines demonstrating a high efficiency in all cell cultures. The fast synthesis by microfluidics of polymeric nanoparticles derived from an amphiphilic block copolymer is optimized to prepare nanocarriers, using naproxen as model, and homogeneous hybrid nanoparticles with encapsulated Pd nanosheets, which are efficiently prepared by in situ reduction of a precursor. These hybrid nanoparticles are not cytotoxic and exhibit excellent properties for photothermal therapy using near infrared as stimulus.
Editor: Germany: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets

Abad, Miriam ; Mendoza, Gracia ; Usón, Laura ; Arruebo, Manuel ; Piñol, Milagros ; Sebastián, Víctor ; Oriol, Luis

Germany: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.