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Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach

Al-Hadrawi, Dhurgham Shihab ; Al-Rubaye, Haneen Tahseen ; Almulla, Abbas F ; Al-Hakeim, Hussein Kadhem ; Maes, Michael

Acta neuropsychiatrica, 2023-04, Vol.35 (2), p.76-87 [Periódico revisado por pares]

England: Cambridge University Press

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Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach
Autor: Al-Hadrawi, Dhurgham Shihab ; Al-Rubaye, Haneen Tahseen ; Almulla, Abbas F ; Al-Hakeim, Hussein Kadhem ; Maes, Michael
Assuntos: Affective Symptoms ; Anxiety ; Biomarkers ; Biomarkers - metabolism ; Body Temperature ; Chronic fatigue syndrome ; COVID-19 ; COVID-19 - complications ; COVID-19 - diagnosis ; Disease transmission ; Fatigue ; Fatigue Syndrome, Chronic - diagnosis ; Female ; Hospitals ; Humans ; Hypoxia ; Illnesses ; Infections ; Mental depression ; Oxygen Saturation ; Post-Acute COVID-19 Syndrome ; Respiratory diseases ; Severe acute respiratory syndrome coronavirus 2 ; Viral infections
É parte de: Acta neuropsychiatrica, 2023-04, Vol.35 (2), p.76-87
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact pathophysiology of the affective, chronic fatigue and physiosomatic symptoms (labelled as "physio-affective phenome") of LC has remained elusive. The current study aims to delineate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on the physio-affective phenome of LC. We recruited 120 LC patients and 36 controls. For all participants, we assessed the lowest SpO2 and peak body temperature during acute COVID-19, and the Hamilton Depression and Anxiety Rating Scale (HAMD/HAMA) and Fibro Fatigue (FF) scales 3-4 months later. Lowered SpO2 and increased body temperature during the acute phase and female sex predict 60.7% of the variance in the physio-affective phenome of LC. Using unsupervised learning techniques, we were able to delineate a new endophenotype class, which comprises around 26.7% of the LC patients and is characterised by very low SpO2 and very high body temperature, and depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms scores. Single latent vectors could be extracted from both biomarkers, depression, anxiety and FF symptoms or from both biomarkers, insomnia, chronic fatigue, gastro-intestinal and autonomic symptoms. The newly constructed endophenotype class and pathway phenotypes indicate that the physio-affective phenome of LC is at least in part the consequence of the pathophysiology of acute COVID-19, namely the combined effects of lowered SpO2, increased body temperature and the associated immune-inflammatory processes and lung lesions.
Editor: England: Cambridge University Press
Idioma: Inglês;Holandês

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Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach

Al-Hadrawi, Dhurgham Shihab ; Al-Rubaye, Haneen Tahseen ; Almulla, Abbas F ; Al-Hakeim, Hussein Kadhem ; Maes, Michael

England: Cambridge University Press

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