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Food-borne melanoidin-based nanozyme mimics natural peroxidase for efficient catalytic disinfection

Sun, Hao ; Lan, Xi ; Wang, Tianyu ; He, Yining ; Dan, Jie ; Kang, Yi ; Liang, Yanmin ; Zhang, Qiuping ; Wang, Jianlong ; Zhang, Wentao

Colloids and surfaces, B, Biointerfaces, 2022-12, Vol.220, p.112948-112948, Article 112948 [Periódico revisado por pares]

Elsevier B.V

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  • Título:
    Food-borne melanoidin-based nanozyme mimics natural peroxidase for efficient catalytic disinfection
  • Autor: Sun, Hao ; Lan, Xi ; Wang, Tianyu ; He, Yining ; Dan, Jie ; Kang, Yi ; Liang, Yanmin ; Zhang, Qiuping ; Wang, Jianlong ; Zhang, Wentao
  • Assuntos: Antibacterial therapy ; Melanoidin/Fe3 ; MRSA ; Peroxidase-like activity ; Superoxide anion
  • É parte de: Colloids and surfaces, B, Biointerfaces, 2022-12, Vol.220, p.112948-112948, Article 112948
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Nanozymes show great potential as broad-spectrum antibacterial agents in the field of anti-infection. Their feasibility of application has received great hindrance due to low catalytic performance, insufficient reactive oxygen species (ROS), complex material design, and biosafety issues. Herein, we discovered an Fe3+-centered Melanoidin/Fe3+ nanozyme that exhibited superior reaction rate and catalytic activity to horseradish peroxidase (HRP) through the carboxyl, nitrogenous structure of Melanoidin. Melanoidin/Fe3+ catalyzed the formation of hydrogen peroxide (H2O2) into highly toxic superoxide anion (O2-•), which promoted the antibacterial ability of H2O2. The results showed that Melanoidin/Fe3+ had an excellent antibacterial effect against methicillin-resistant Staphylococcus aureus (MRSA) in low concentration H2O2 system. Both the infection wound model experiment and the biocompatibility experiment showed that the Melanoidin/Fe3+ promoted wound healing and had impressive biosafety. Thus, Melanoidin/Fe3+ shows ideal promise for the design of artificial enzymes with catalytic properties comparable to those of natural enzymes and clinical antibacterial therapy. [Display omitted] •Food-borne melanoidin from soybean sauce was applied.•Melanoidin/Fe3+ was facilely synthesized at room temperature.•Melanoidin/Fe3+ has high catalytic activity, biocompatibility, and antibacterial performance.•Antibacterial activity works through O2-• inducing cell destruction.
  • Editor: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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