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The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats

Kaneguchi, Akinori ; Takahashi, Akira ; Shimoe, Atsuhiro ; Hayakawa, Momoka ; Yamaoka, Kaoru ; Ozawa, Junya

Steroids, 2023-04, Vol.192, p.109183-109183, Article 109183 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats
Autor: Kaneguchi, Akinori ; Takahashi, Akira ; Shimoe, Atsuhiro ; Hayakawa, Momoka ; Yamaoka, Kaoru ; Ozawa, Junya
Assuntos: ACL reconstruction ; Animals ; Anterior Cruciate Ligament Injuries - pathology ; Anterior Cruciate Ligament Injuries - surgery ; Anterior Cruciate Ligament Reconstruction - methods ; Anterior Cruciate Ligament Reconstruction - rehabilitation ; Contracture - drug therapy ; Contracture - etiology ; Contracture - pathology ; Dexamethasone - pharmacology ; Dexamethasone - therapeutic use ; Exercise ; Fibrosis ; Joint contracture ; Muscle atrophy ; Muscular Atrophy - drug therapy ; Muscular Atrophy - etiology ; Muscular Atrophy - pathology ; Osteophyte - pathology ; Osteophyte - surgery ; Quadriceps Muscle - pathology ; Quadriceps Muscle - surgery ; Rats ; Steroid
É parte de: Steroids, 2023-04, Vol.192, p.109183-109183, Article 109183
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: •Rehabilitation protocols following ACL reconstruction have not been established.•We examined the combined effects of exercise therapy and steroid administration.•Steroid improved joint contracture but delayed recovery from muscle atrophy.•Treadmill exercise attenuated the muscle atrophy but did not improve contracture.•The combined treatment improved both joint contracture and muscle atrophy. Rehabilitation protocols to treat joint contracture and muscle atrophy following anterior cruciate ligament (ACL) reconstruction have not been established. In this study, we examined the combined effects of exercise therapy and steroid administration on joint contracture and muscle atrophy following ACL reconstruction. Rats received ACL transection and reconstructive surgery in one knee. After surgery, they were divided into four groups: no intervention, treadmill exercise (started from day three post-surgery, 12 m/min, 60 min/d, 6 d/week), treatment with the steroidal drug dexamethasone (250 μg/kg on days 0–5, 7, and 9 post-surgery), and dexamethasone treatment plus treadmill exercise. Age-matched untreated rats were used as controls. At day 10 or 30 post-surgery, we assessed ACL-reconstruction–induced joint contracture, joint capsule fibrosis, osteophyte formation, and muscle atrophy of the rectus femoris and gastrocnemius. Treadmill exercise after ACL reconstruction improved several indicators of muscle atrophy in both muscles, but it did not have positive effects on joint contracture. Dexamethasone treatment after ACL reconstruction improved joint contracture and joint capsule fibrosis at both timepoints and partially attenuated osteophyte formation at day 10 post-surgery, but delayed recovery from atrophy of the rectus femoris at day 30 post-surgery. The two treatments combined improved both joint contracture and atrophy of the rectus femoris and gastrocnemius. Exercise therapy combined with steroid administration may therefore be a novel therapeutic strategy for joint contracture and muscle atrophy following ACL reconstruction.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats

Kaneguchi, Akinori ; Takahashi, Akira ; Shimoe, Atsuhiro ; Hayakawa, Momoka ; Yamaoka, Kaoru ; Ozawa, Junya

United States: Elsevier Inc

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