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(m-CF3-PhSe)2 benefits against anxiety-like phenotype associated with synaptic plasticity impairment and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model

Müller, Sabrina G. ; Jardim, Natália S. ; Lutz, Guilherme ; Zeni, Gilson ; Nogueira, Cristina W.

Chemico-biological interactions, 2023-06, Vol.378, p.110486-110486, Article 110486 [Periódico revisado por pares]

Ireland: Elsevier B.V

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  • Título:
    (m-CF3-PhSe)2 benefits against anxiety-like phenotype associated with synaptic plasticity impairment and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model
  • Autor: Müller, Sabrina G. ; Jardim, Natália S. ; Lutz, Guilherme ; Zeni, Gilson ; Nogueira, Cristina W.
  • Assuntos: Animals ; Anti-Anxiety Agents - pharmacology ; Anxiety ; Anxiety - drug therapy ; Anxiety Disorders ; Benzene Derivatives - pharmacology ; Ethanol ; Food ; Male ; Mice ; Motor Activity ; Neurotoxicity ; Organoselenium Compounds - pharmacology ; Phenotype ; Selenium
  • É parte de: Chemico-biological interactions, 2023-06, Vol.378, p.110486-110486, Article 110486
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Lifestyle habits including energy-dense foods and ethanol intake are associated with anxiety disorders. m-Trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] has been reported to modulate serotonergic and opioidergic systems and elicit an anxiolytic-like phenotype in animal models. This study investigated if the modulation of synaptic plasticity and NMDAR-mediated neurotoxicity contributes to the (m-CF3-PhSe)2 anxiolytic-like effect in young mice exposed to a lifestyle model. Swiss male mice (25-days old) were subjected to a lifestyle model, an energy-dense diet (20:20% lard: corn syrup) from the postnatal day (PND) 25–66 and sporadic ethanol (2 g/kg) (3 x a week, intragastrically, i.g.) from PND 45 to 60. From PND 60 to 66, mice received (m-CF3-PhSe)2 (5 mg/kg/day; i.g). The corresponding vehicle (control) groups were carried out. After, mice performed anxiety-like behavioral tests. Mice exposed only to an energy-dense diet or sporadic ethanol did not show an anxiety-like phenotype. (m-CF3-PhSe)2 abolished the anxiety-like phenotype in young mice exposed to a lifestyle model. Anxious-like mice showed increased levels of cerebral cortical NMDAR2A and 2B, NLRP3 and inflammatory markers, and decreased contents of synaptophysin, PSD95, and TRκB/BDNF/CREB signaling. (m-CF3-PhSe)2 reversed cerebral cortical neurotoxicity, the increased levels of NMDA2A and 2B, and decreased levels of synaptic plasticity-related signaling in the cerebral cortex of young mice exposed to a lifestyle model. In conclusion, the (m-CF3-PhSe)2 anxiolytic-like effect was associated with the modulation of NMDAR-mediated neurotoxicity and synaptic plasticity in the cerebral cortex of young mice exposed to the lifestyle model. [Display omitted] •A lifestyle model induces anxiety-like phenotype in young mice.•(m-CF3-PhSe)2 abolishes the anxiety-like phenotype in young mice.•(m-CF3-PhSe)2 counteracts NDMAR-mediated neurotoxicity in anxious mice.•Synaptic plasticity improvement contributes to the (m-CF3-PhSe)2 anxiolytic-like effects.•Anti-inflammatory properties are related to (m-CF3-PhSe)2 beneficial effects.
  • Editor: Ireland: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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