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Optical fiber surface plasmon resonance sensor using electroless-plated gold film for thrombin detection

Huang, Yu ; Pu, Xiaoyin ; Qian, Husun ; Chuang, Chin-Jung ; Dong, Shanshan ; Wu, Jiangling ; Xue, Jianjiang ; Cheng, Wei ; Ding, Shijia ; Li, Shengqiang

Analytical and bioanalytical chemistry, 2024-03, Vol.416 (6), p.1469-1483 [Revista revisada por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Optical fiber surface plasmon resonance sensor using electroless-plated gold film for thrombin detection
Autor: Huang, Yu ; Pu, Xiaoyin ; Qian, Husun ; Chuang, Chin-Jung ; Dong, Shanshan ; Wu, Jiangling ; Xue, Jianjiang ; Cheng, Wei ; Ding, Shijia ; Li, Shengqiang
Materias: Analytical Chemistry ; Aptamers ; Biochemistry ; Biosensing Techniques - methods ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Electroless plating ; Food Science ; Gold ; Laboratory Medicine ; Metal Nanoparticles ; Monitoring methods ; Monitoring/Environmental Analysis ; Nanoparticles ; Optical Fibers ; Polyadenine ; Refractivity ; Research Paper ; Resonance ; Sensors ; Surface plasmon resonance ; Surface Plasmon Resonance - methods ; Thrombin ; Wavelength
Es parte de: Analytical and bioanalytical chemistry, 2024-03, Vol.416 (6), p.1469-1483
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descripción: This paper describes the simple and label-free detection of thrombin using optical fiber surface plasmon resonance (SPR) sensors based on gold films prepared by the cost-effective method of electroless plating. The plating conditions for simultaneously obtaining gold film on cylindrical core and end surfaces of an optical fiber suitable for measurement were optimized. The fabricated sensor exhibited a linear refractive index sensitivity of 2150 nm/RIU and 7.136 (a.u.)/RIU in the refractive index of 1.3329–1.3605 interrogated by resonance wavelength and amplitude methods respectively and a single wavelength monitoring method was proposed to investigate the sensing performance of this sensor. Polyadenine diblock and thiolated thrombin aptamers were immobilized on gold nanoparticles and gold films respectively to implement a sandwich optical fiber assay for thrombin. The developed optical fiber SPR sensors were successfully used in the determination of thrombin down to 0.56 nM over a wide range from 2 to 100 nM and showed good selectivity for thrombin, which indicated their potential clinical applications for biomedical samples. Graphical Abstract
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglés

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Optical fiber surface plasmon resonance sensor using electroless-plated gold film for thrombin detection

Huang, Yu ; Pu, Xiaoyin ; Qian, Husun ; Chuang, Chin-Jung ; Dong, Shanshan ; Wu, Jiangling ; Xue, Jianjiang ; Cheng, Wei ; Ding, Shijia ; Li, Shengqiang

Berlin/Heidelberg: Springer Berlin Heidelberg

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