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Asymmetric neurons are necessary for olfactory learning in the Drosophila brain

Abubaker, Mohammed Bin ; Hsu, Fu-Yu ; Feng, Kuan-Lin ; Chu, Li-An ; de Belle, J. Steven ; Chiang, Ann-Shyn

Current biology, 2024-03, Vol.34 (5), p.946-957.e4 [Revista revisada por pares]

England: Elsevier Inc

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  • Título:
    Asymmetric neurons are necessary for olfactory learning in the Drosophila brain
  • Autor: Abubaker, Mohammed Bin ; Hsu, Fu-Yu ; Feng, Kuan-Lin ; Chu, Li-An ; de Belle, J. Steven ; Chiang, Ann-Shyn
  • Materias: Animals ; asymmetric body ; Brain - metabolism ; CS+ avoidance ; CS− attraction ; depression memory trace ; Drosophila - metabolism ; Drosophila melanogaster - physiology ; Drosophila Proteins - metabolism ; Learning - physiology ; Mushroom Bodies - physiology ; Neurons - physiology ; parallel processing ; Smell - physiology ; STM acquisition
  • Es parte de: Current biology, 2024-03, Vol.34 (5), p.946-957.e4
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descripción: Animals have complementary parallel memory systems that process signals from various sensory modalities. In the brain of the fruit fly Drosophila melanogaster, mushroom body (MB) circuitry is the primary associative neuropil, critical for all stages of olfactory memory. Here, our findings suggest that active signaling from specific asymmetric body (AB) neurons is also crucial for this process. These AB neurons respond to odors and electric shock separately and exhibit timing-sensitive neuronal activity in response to paired stimulation while leaving a decreased memory trace during retrieval. Our experiments also show that rutabaga-encoded adenylate cyclase, which mediates coincidence detection, is required for learning and short-term memory in both AB and MB. We observed additive effects when manipulating rutabaga co-expression in both structures. Together, these results implicate the AB in playing a critical role in associative olfactory learning and short-term memory. [Display omitted] •ABIN neurotransmission is necessary during aversive olfactory conditioning•ABIN responses are enhanced during acquisition and depressed during retrieval•ABIN neurotransmission is necessary for CS− attraction while not for CS+ avoidance•ABINs contribute to STM formation in parallel with MB in a Rut-dependent manner Abubaker et al. investigate the significance of ABINs in short-term memory formation. They emphasize the role of ABIN neurotransmission during learning, coincidence detection, and distinction of signals leading to avoidance and attraction memories. These findings reveal novel ABIN functions in associative olfactory conditioning and memory formation.
  • Editor: England: Elsevier Inc
  • Idioma: Inglés
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