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Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis

Liu, Xinlei ; Liu, Rui ; Wang, Yancheng

Biochemical and biophysical research communications, 2024-05, Vol.710, p.149880-149880, Article 149880 [Periódico revisado por pares]

United States: Elsevier Inc

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Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis
Autor: Liu, Xinlei ; Liu, Rui ; Wang, Yancheng
Assuntos: Acetaminophen ; Acetaminophen - adverse effects ; Alanine Transaminase ; Animals ; Apoptosis ; Aspartate Aminotransferases ; Chemical and Drug Induced Liver Injury - drug therapy ; Chemical and Drug Induced Liver Injury - metabolism ; Chemical and Drug Induced Liver Injury - prevention & control ; Chemical and Drug Induced Liver Injury, Chronic - pathology ; Glutathione - metabolism ; Indole-3-carboxaldehyde ; Indoles ; Liver - metabolism ; Liver injury ; Mice ; Oxidative Stress
É parte de: Biochemical and biophysical research communications, 2024-05, Vol.710, p.149880-149880, Article 149880
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Drug-induced liver injury (DILI) occurs frequently and can be life-threatening. Increasing researches suggest that acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury. Indole-3-carboxaldehyde (I3A) alleviates hepatic inflammation, fibrosis and atherosclerosis, suggesting a potential role in different disease development. However, the question of whether and how I3A protects against acetaminophen-induced liver injury remains unanswered. In this study, we demonstrated that I3A treatment effectively mitigates acetaminophen-induced liver injury. Serum alanine/aspartate aminotransferases (ALT/AST), liver malondialdehyde (MDA) activity, liver glutathione (GSH), and superoxide dismutase (SOD) levels confirmed the protective effect of I3A against APAP-induced liver injury. Liver histological examination provided further evidence of I3A-induced protection. Mechanistically, I3A reduced the expression of apoptosis-related factors and oxidative stress, alleviating disease symptoms. Finally, I3A treatment improved survival in mice receiving a lethal dose of APAP. In conclusion, our study demonstrates that I3A modulates hepatotoxicity and can be used as a potential therapeutic agent for DILI. •I3A alleviated APAP-induced acute liver injury.•I3A attenuated APAP-provoked liver oxidative stress.•I3A attenuated hepatic necrosis in APAP-induced acute liver injury mice.•I3A can improve the survival of lethal doses of APAP-induced mice.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis

Liu, Xinlei ; Liu, Rui ; Wang, Yancheng

United States: Elsevier Inc

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