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Reduced sympathetic activity is associated with the development of pain and muscle atrophy in a female rat model of fibromyalgia

da Silva, Raquel Prado ; Costa, Daniely Messias ; da Cruz-Filho, João ; Santos, Tatiane de Oliveira ; dos Anjos-Santos, Hevely Catharine ; Vasconcelos, Alan Bruno Silva ; Heck, Lilian Carmo ; Kettelhut, Ísis do Carmo ; Navegantes, Luiz Carlos ; dos Santos, José Ronaldo ; de Souza, Patrícia Rodrigues Marques ; Badauê-Passos Jr, Daniel ; Mecawi, André Souza ; DeSantana, Josimari Melo ; Lustrino, Danilo

Physiology & behavior, 2024-07, Vol.281, p.114575-114575, Article 114575 [Revista revisada por pares]

United States: Elsevier Inc

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Reduced sympathetic activity is associated with the development of pain and muscle atrophy in a female rat model of fibromyalgia
Autor: da Silva, Raquel Prado ; Costa, Daniely Messias ; da Cruz-Filho, João ; Santos, Tatiane de Oliveira ; dos Anjos-Santos, Hevely Catharine ; Vasconcelos, Alan Bruno Silva ; Heck, Lilian Carmo ; Kettelhut, Ísis do Carmo ; Navegantes, Luiz Carlos ; dos Santos, José Ronaldo ; de Souza, Patrícia Rodrigues Marques ; Badauê-Passos Jr, Daniel ; Mecawi, André Souza ; DeSantana, Josimari Melo ; Lustrino, Danilo
Materias: Adrenergic beta-Agonists - pharmacology ; Animals ; Carrageenan - toxicity ; Catecholamines - metabolism ; Clenbuterol - pharmacology ; Disease Models, Animal ; Epinephrine ; Female ; Fibromyalgia ; Fibromyalgia - pathology ; Fibromyalgia - physiopathology ; Hyperalgesia ; Hyperalgesia - pathology ; Hyperalgesia - physiopathology ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - pathology ; Muscular Atrophy - physiopathology ; Pain - pathology ; Pain - physiopathology ; Proteolysis ; Rats ; Rats, Sprague-Dawley ; Skeletal muscle ; Sympathetic nervous system ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - pathology ; Sympathetic Nervous System - physiopathology
Es parte de: Physiology & behavior, 2024-07, Vol.281, p.114575-114575, Article 114575
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SourceType-Scholarly Journals-1
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Descripción: •Plasma epinephrine is decreased in priming models of fibromyalgia-like pain.•Clenbuterol attenuates hyperalgesia in an acid saline-induced fibromyalgia-like pain model.•Clenbuterol mitigates muscle atrophy in fibromyalgia priming model. Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain accompanied by fatigue and muscle atrophy. Although its etiology is not known, studies have shown that FM patients exhibit altered function of the sympathetic nervous system (SNS), which regulates nociception and muscle plasticity. Nevertheless, the precise SNS-mediated mechanisms governing hyperalgesia and skeletal muscle atrophy in FM remain unclear. Thus, we employed two distinct FM-like pain models, involving intramuscular injections of acidic saline (pH 4.0) or carrageenan in prepubertal female rats, and evaluated the catecholamine content, adrenergic signaling and overall muscle proteolysis. Subsequently, we assessed the contribution of the SNS to the development of hyperalgesia and muscle atrophy in acidic saline-injected rats treated with clenbuterol (a selective β2-adrenergic receptor agonist) and in animals maintained under baseline conditions and subjected to epinephrine depletion through adrenodemedullation (ADM). Seven days after inducing an FM-like model with acidic saline or carrageenan, we observed widespread mechanical hyperalgesia along with loss of strength and/or muscle mass. These changes were associated with reduced catecholamine content, suggesting a common underlying mechanism. Notably, treatment with a β2-agonist alleviated hyperalgesia and prevented muscle atrophy in acidic saline-induced FM-like pain, while epinephrine depletion induced mechanical hyperalgesia and increased muscle proteolysis in animals under baseline conditions. Together, the results suggest that reduced sympathetic activity is involved in the development of pain and muscle atrophy in the murine model of FM analyzed.
Editor: United States: Elsevier Inc
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Reduced sympathetic activity is associated with the development of pain and muscle atrophy in a female rat model of fibromyalgia

United States: Elsevier Inc

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